P2O5 Assisted Green Synthesis of Multicolor Fluorescent Water Soluble Carbon Dots (original) (raw)
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Recent advance of carbon dots in bio-related applications
Journal of Physics: Materials, 2020
Carbon dots (CDs) is a kind of carbon nanoparticles with a plentiful of surface functional groups and tunable emission with different excitation wavelength. Broadly speaking, CDs include carbon nanodots, carbon quantum dots, graphene quantum dots, carbonized polymer dots. Due to the unique nature, they are explored for various applications in the bio-related fields such as bioimaging, sensor for ion and (bio)molecules, catalyst, LED and other fields. They are viewed as great alternative tracers to the current fluorescent biomarkers in personalized nanomedicine and surgery operation monitoring. In this review, we summarized the recent progress in the development of CDs, including improvement in fluorescence properties, two-photon fluorescence, and integration with other modalities as theragnostic agents. Specifically, we discussed the preparation of dual-modal imaging agents to improve the accuracy of diagnosis, the combination of imaging and targeting functionality for the effective...
Advances in fluorescent carbon dots for biomedical applications
Advances in Physics: X
Carbon Dots are an emerging class of carbon-based nanoparticles, which since their discovery have attracted tremendous attention because of their exceptional fluorescent, chemical and mechanical properties as well as high photostability and biocompatibility. This unique combination of outstanding characteristics, together with the ease with which they can be synthesized, qualify carbon dots as highly promising materials for applications in electronics and biology, in particular, for biosensing, bioimaging, biotherapy and drug delivery. In this review, we present some of the most recent applications of carbon dots in biology and medicine, concentrating on their fluorescence properties, biocompatibility and efficiency; we also discuss how improvements could prompt their use in human studies. We illustrate how carbon dots, prepared through several facile and costeffective methods by either the bottom-up or the top-down route, can be used for imaging cells and bacteria and as sensing probes of metal cations. Moreover, we explain how their astonishing versatility has given rise to new biotherapy methods especially in the field of cancer theranostics.
Carbon Dots as Nontoxic and High-Performance Fluorescence Imaging Agents
Fluorescent carbon dots (small carbon nanoparticles with the surface passivated by oligomeric PEG molecules) were evaluated for their cytotoxicity and in vivo toxicity and also for their optical imaging performance in reference to that of the commercially supplied CdSe/ZnS quantum dots. The results suggested that the carbon dots were biocompatible, and their performance as fluorescence imaging agents was competitive. The implication to the use of carbon dots for in vitro and in vivo applications is discussed.
Biocompatible Carbon Nanodots for Functional Imaging and Cancer Therapy
International Journal of Biomedical and Clinical Engineering, 2018
This article describes how carbon quantum dots (C-dots) are tiny carbon nanoparticles (less than 10 nm in size) being envisaged to be used in bio-sensing, bio-imaging and drug delivery nanosystems. Their low toxicity and stable chemical properties make them suitable candidates for new types of fluorescent probe, which overcome the common drawbacks of previous fluorescent probes (organic dyes and inorganic quantum dots). In addition, fluorescent C-dots possess a rather strong ability to bind with other organic and inorganic molecules due to their abundant surface groups. For that reason, fluorescent C-dots can be manipulated via series of controllable chemical treatments in order to satisfy the demands in the photocatalytic, biochemical and chemical sensing, bio-imaging, drug delivery and enhanced cell targeting. In recent studies it was described the development of carbon quantum dots with large two-photon absorption cross sections towards two-photon imaging for use in photodynamic ...
This article describes how carbon quantum dots (C-dots) are tiny carbon nanoparticles (less than 10 nm in size) being envisaged to be used in bio-sensing, bio-imaging and drug delivery nanosystems. Their low toxicity and stable chemical properties make them suitable candidates for new types of fluorescent probe, which overcome the common drawbacks of previous fluorescent probes (organic dyes and inorganic quantum dots). In addition, fluorescent C-dots possess a rather strong ability to bind with other organic and inorganic molecules due to their abundant surface groups. For that reason, fluorescent C-dots can be manipulated via series of controllable chemical treatments in order to satisfy the demands in the photocatalytic, biochemical and chemical sensing, bio-imaging, drug delivery and enhanced cell targeting. In recent studies it was described the development of carbon quantum dots with large two-photon absorption cross sections towards two-photon imaging for use in photodynamic cancer therapy. Thus, C-dots have become a rising star in biomedical research with a promising future for the application in nanomedicine.
Recent Developments in Carbon Quantum Dots: Properties, Fabrication Techniques, and Bio-Applications
2021
Carbon dots have gained tremendous interest attributable to their unique features. Two approaches are involved in the fabrication of quantum dots (Top-down and Bottom-up). Most of the synthesis methods are usually multistep, required harsh conditions, and costly carbon sources that may have a toxic effect, therefore green synthesis is more preferable. Herein, the current review presents the green synthesis of carbon quantum dots (CQDs) and graphene quantum dots (GQDs) that having a wide range of potential applications in bio-sensing, cellular imaging, and drug delivery. However, some drawbacks and limitations are still unclear. Other biomedical and biotechnological applications are also highlighted.
MULTI-FUNCTIONAL CARBON DOTS: A SYSTEMATIC OVERVIEW Review Article
International Journal of Applied Pharmaceutics, 2021
Carbon dots (CDs) have emerged as a potential material in the multifarious fields of biomedical applications due to their numerous advantageous properties including tunable fluorescence, water solubility, biocompatibility, low toxicity, small size and ease of modification, inexpensive scale-up production, and versatile conjugation with other targeted nanoparticles. Thus, CDs became a preferable choice in various biomedical applications such as nanocarriers for drugs, therapeutic genes, photo sensitizers, unique electronic, fluorescent, photo luminescent, chemiluminescent, and electro chemiluminescent, drug/gene delivery and optoelectronics properties are what gives them potential in sensing and antibacterial molecules. Further, their potentials have also been verified in multifunctional diagnostic platforms, cellular and bacterial bio-imaging, development of nanomedicine, etc. This present review provides a concise insight into the progress and evolution in the field of carbon dots research with respect to synthesis methods and materials available in bio-imaging, theranostic, cancer, gene therapy, diagnostics, etc. Further, our discussion is extended to explore the role of CDs in nanomedicine and nano theranostic, biotherapy which is the future of biomedicine and also serves to discuss the various properties of carbon dots which allow chemotherapy and gene therapy to be safer and more target-specific, resulting in the reduction of side effects experienced by patients and also the overall increase in patient compliance and quality of life and representative studies on their activities against bacteria, fungi, and viruses reviewed and discussed. This study will thus help biomedical researchers in percuss the potential of CDs to overcome various existing technological challenges.
Journal of Nanoparticle Research, 2017
In this study, comparative evaluation of fluorescent carbon nanodots (C-Dots) prepared using carob molasses was reported by screening various biocompatible macromolecules as passivating agent (PA). Incorporation of PAs with different molecular weight, polarity, and chemical structure was examined, and compared with the polyethylene glycol (PEG, Mn = 10 kN) passivated and pristine C-Dots. Not only the fluorescence properties but also many other features including size, crystal structure, colloidal conductivity, resistance to photobleaching, quantum yield, and UV-modulated surface interaction of them with the reactive oxygen species (ROS) as well as ROS production were investigated. Photoluminescence (PL) capacity of C-Dots was found to be associated with the number of surface alkyl groups and polymeric hydrogen bounding present on the C-Dot surface (increased number is associated with decreased PL) while surface conductivity of C-Dots in water was proportional to the PL intensity. More importantly, C-Dots with relatively poorer fluorescent were investigated in various organic solvents (hexane, methanol, acetone, ethanol, dimethylformamide (DMF), and DMSO). As happens with the fluorescent dyes, their PL intensities were significantly enhanced (even for pristine C-Dots) depending on the solvent characteristics. All of the C-Dots synthesized were further evaluated by means of UV-induced generation of ROS and inhibition of ROS by using H 2 O 2 as model. In contrary to other carbonaceous nanomaterials, they did not show any ROS generation, on the contrary, they showed ROS scavenging activity that can be modulated by UVirradiation (λ exc = 365 nm). PEG and alginate passivated C-Dots inhibited H 2 O 2 activity at LC 50 values below 10 mg/mL.
Carbon dots—Emerging light emitters for bioimaging, cancer therapy and optoelectronics
Nano Today, 2014
Carbon dots represent an emerging class of fluorescent materials and provide a broad application potential in various fields of biomedicine and optoelectronics. In this review, we introduce various synthetic strategies and basic photoluminescence properties of carbon dots, and then address their advanced in vitro and in vivo bioapplications including cell imaging, photoacoustic imaging, photodynamic therapy and targeted drug delivery. We further consider the applicability of carbon dots as components of light emitting diodes, which include carbon dot based electroluminescence, optical down-conversion, and hybrid plasmonic devices. The review concludes with an outlook towards future developments of these emerging light-emitting materials.