Constancy of ERp29 Expression in Cultured Retinal Pigment Epithelial Cells in the Ccl2/Cx3cr1 Deficient Mouse Model of Age-Related Macular Degeneration (original) (raw)

Age-related macular degeneration (AMD) is a leading cause of vision loss, with retinal pigment epithelium (RPE) dysfunction being a significant factor. This study investigates the expression of ERp29, a chaperone protein, in RPE cells taken from Ccl2/Cx3cr1 deficient mice, a model that mimics AMD characteristics. Using innovative RPE culturing techniques, the research shows consistent expression patterns of ERp29 in the RPE of both wild-type and deficient mice, contributing to our understanding of AMD pathology and the role of chaperone proteins in retinal health.