Bradykinin signal pathways modulate neurohypophyseal hormones secretion (original) (raw)

2014

Abstract

ABSTRACT Afferent renal nerves stimulate vasopressin (VP) secretion by activation of VPergic neurons of SON and PVN. Intrarenal infusion of bradykinin (BK), which excites afferent renal nerves, increases VP release. However, BK is also a potent intrarenal vasodilator hence BK may modulate VPsecretion stimulating its release via afferent renal nerves and inhibiting its renal effects as intrarenal vasodilator via a paracrine control. BK impaired the mechanism of phosphorilation that induces the traslocation of vescicles containing aquaporin-2 to the apical plasma membrane thus inhibiting the osmotic water permeability of collecting duct cells provoked by VP via its V2 receptor, In addition, BKB2 receptor knockout mice exhibit decreased urine output and increased urine osmolality following water deprivation. Oxytocin (OT) increases urine volume and sodium excretion in rats. Icatibant, a BKB2 antagonist, suppress these effects showing that BK mediates diuresis and natriuresis induced by OT. Infusion of OT down-regulated myometrial OT and BK receptors indicating the existence of a common final pathway of OT and BK in the contractile responsiveness of uterine myometrial cells

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