Smad proteins and transforming growth factor-beta signaling (original) (raw)

This paper discusses the roles of Smad proteins in the transforming growth factor-beta (TGF-β) signaling pathway, particularly in relation to kidney development and pathology. It highlights the dual functions of TGF-β in inducing renal fibrosis and regulating vascular tone, along with the molecular mechanisms that mediate these effects through R-Smads. The findings indicate that TGF-β acts as a central regulator in various renal diseases, contributing to both profibrotic processes and acute injury responses.