Response to "Analysis and interpretation of 24 hour blood pressure profiles (original) (raw)

The response critically evaluates the methods used to analyze ambulatory blood pressure recordings, addressing concerns about over or under modeling based on data quality. It compares different mathematical approaches for assessing the morning blood pressure surge (MBPS) and highlights the limitations of traditional models like the Minnesota Cosinor equation and the square wave model. The authors propose that a mathematical determination of peak timing, independent of waking time, may offer better insights into cardiovascular risk associated with morning surges, and suggest a need for more robust statistical comparisons between various modeling techniques.