Localization of serotonin receptors in the rat thalamus by electrophysiology and the action of 5-HTP-DP-hex (original) (raw)

This study investigates the localization and effects of N-hexanoyl-6-hydroxytryptophyl-5-hydroxytryptophan amide (5-HTP-DP-hex) on thalamic neurons in rats. Using a stereotaxic approach, the researchers activated individual neurons in the nucleus ventralis posterolateralis (nVPL) and the centrum medianum-parafascicularis complex (CM-Pf). Results indicated that 5-HTP-DP-hex selectively suppressed excitatory responses of CM-Pf neurons linked to the second somatosensory region, potentially revealing the role of serotonin receptors in pain modulation within these thalamic regions.