Polymorphisms of the antiapoptotic protein bag3 may play a role in the pathogenesis of tako-tsubo cardiomyopathy (original) (raw)

This study investigates the role of BAG3 gene polymorphisms in tako-tsubo cardiomyopathy (TTC), a condition characterized by transient left ventricular dysfunction often triggered by stress. It compares the frequency of specific polymorphisms in a cohort of 29 TTC patients against a large sample of over 1000 healthy controls. Notably, significant differences were observed in the presence of certain BAG3 variants, suggesting a potential genetic predisposition to TTC, which may influence the disease's pathogenesis. The findings highlight the importance of understanding genetic factors in cardiovascular diseases.