Long term, low-dose tigecycline to treat relapsing bloodstream infection due to KPC-producing Klebsiella pneumoniae after major hepatic surgery (original) (raw)

2015, International Journal of Infectious Diseases

A 68 years-old male underwent right hepatectomy, resection of biliary carrefour and left hepaticjejunostomy for a Klatskin cancer. The post-operative course was complicated by biliary abscesses with relapsing bloodstream infections due to KPC carbapenemase-producing Klebsiella pneumoniae (KPC-Kp). A two-week course of combination antibiotic therapy failed to obtain source control and bacteremia relapsed. Success was obtained with a regimen of tigecycline 100 mg qd for two months, followed by tigecycline 50 mg qd for six months, then 50 mg every 48 hours for three months. No side effects were reported.