Time dependent changes in cytoplasmic proteins of the right ventricle during prolonged pressure overload (original) (raw)

This research investigates the changes in cytoplasmic proteins of the right ventricle in response to prolonged pressure overload conditions, commonly experienced in congenital heart disease (CHD) patients. The study highlights how prolonged right ventricular (RV) pressure overload can lead to alterations in heart function at both cellular and molecular levels, ultimately contributing to RV failure. Through statistical measures of cardiac function over various time points of pressure overload, significant shifts in cardiac performance are documented, emphasizing the need for deeper understanding of the molecular adaptations in response to chronic pressure conditions.