Extensive and enantioselective presystemic metabolism of dl-threo-methylphenidate in humans (original) (raw)

1991, Progress in Neuro-Psychopharmacology and Biological Psychiatry

AI-generated Abstract

Extensive presystemic metabolism of dl-threo-methylphenidate (MPH) was investigated in a cohort of children with ADHD, comparing immediate release (MPH-IR) and slow release (MPH-SR) formulations. Results indicated significantly higher plasma levels of the active d-MPH isomer compared to the l-MPH isomer for both formulations, highlighting the pronounced presystemic metabolism of l-MPH. Additionally, the MPH-SR formulation allowed for extended monitoring of l-MPH, suggesting a potential advantage in administration timing.

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