Biocompatible and Biodegradable Biopolymer Matrix (original) (raw)
Related papers
Recent Patents on Biomedical Engineering, 2010
In recent years polymer science has been developed enormously. Researchers have made some significant discoveries and advancements in this field. All these things have lead to a new era of polymer science especially biodegradable polymers. Today a number of biopolymers are known and used for different purposes in biomedical applications. Biodegradable polymers have played a significant role in therapeutics and drug delivery. These biopolymers are advantageous in tissue engineering and other drug delivery systems. A number of biopolymers and their blends are available in market with various physical, chemical and biological properties. The suitability of polymer for biomedical applications depends on its biocompatibility, degradation process (metabolites) and non-immunogenic property. This review summarizes different polymers, their physiological characters, and their use in biomedical applications along with the compilation of recent patents related to biodegradable polymers.
Springer, 2023
Biodegradable polymers are a rapidly growing field driven by increasing concerns about plastic waste and its environmental impact. Polymers prepared from inexpensive and renewable raw materials might be the perfect alternative to plastics, and the properties like biodegradability and biocompatibility make them suitable for various biomedical applications. The biodegradability of the polymers is controllable by altering the monomer concentration and adding hydrolytically degradable groups in the polymeric backbone. These biopolymers can provide a safe and effective way of preparing devices/implantable materials for various biomedical applications. This chapter discusses biodegradable polymers, their synthesis, biodegradability, biocompatibility, along with their advantages and disadvantages for various biomedical applications, including drug delivery and tissue engineering.
Biopolymers; Definition, Classification and Applications
Egyptian Journal of Chemistry, 2019
D URING recent years significant advances have been made in using and development of biodegradable polymeric materials for life applications. Degradable polymeric biomaterials are preferred because these materials have specific physical, chemical, biological, biomechanical and degradation properties. Wide ranges of natural or synthetic biopolymers capable of undergoing degradation hydrolytically or enzymatically are being investigated for many applications. This review aimed to provide an overview for the importance of biomaterials, produced or degraded naturally, classification and applications.
Recent developments in biodegradable synthetic polymers
2006
This chapter reviews recent developments in biodegradable synthetic polymers focusing on tailoring polymer structures to meet material specification for emerging applications such as tissue engineered products and therapies. Major classes and new families of synthetic polymers are discussed with regard to synthesis, properties and biodegradability, and known degradation modes and products are summarized based on studies reported during the past 10–15 years. Polyesters and their copolymers, polyurethanes, polyphosphazenes, polyanhydrides, polycarbonates, polyesteramides and recently developed injectable polymer systems based on polypropylenefumarates, polyurethanes and acrylate/urethane systems are reviewed. Polyesters such as polyglycolides, polylactides and their copolymers still remain as the major class of synthetic biodegradable polymers with products in clinical use. Although various copolymerization methods have addressed needs of different applications, release of acidic degradation products, processing difficulties and limited range of mechanical properties remains as major disadvantages of this family of polymers. Injectable polymers based on urethane and urethane/acrylate have shown great promise in developing delivery systems for tissue engineered products and therapies.
Biodegradable polymers-an overview
Polymers for Advanced Technologies, 2014
The revelation of biodegradable polymers dates back to many years ago. From then, their emergence leads to the surge of many biomaterials applicable in various fields like controlled drug delivery, regenerative medicine, orthopedic and long-term implants which proved out to be momentous contributions of these materials. The immense effort and investigation kept on these materials are reflected by significant upsurge of the biodegradable polymer-based marketed products and ongoing clinical trials of these materials. The synthetic versatility and flexible features of these polymers to get custom designed in accordance with need make them attractive for various therapeutic strategies. Long-term biocompatibility and avoidance of surgery to remove implants are the main advantages of biodegradable materials over biostable polymers by which the former stand in for various indications over the latter. This review gives an overview on various biodegradable polymers with details on properties, mode of degradation and the potential biomedical applications associated with them.
Versatility of biodegradable biopolymers: degradability and an in vivo application
Journal of Biotechnology, 2001
Biodegradable materials have various important applications in the biomedical field. There are basically two groups of polyesters which have significant importance in this field. These are polylactides and polyhydroxybutyrates. Both groups degrade via hydrolysis with the rates of degradation depending on medium properties such as pH, temperature, solvent and presence of biocatalysts, as well as on chemical compositions. In order for these biomaterials to be suitable for use in load bearing applications without deformation or warping their strengths and their capability to maintain their form must be improved. To insure dimensional stability during degradation and to match modulus and strength to that of bone, introduction of a reinforcing structure for those applications to plate fixation through the creation of an interpenetrating network might be a feasible approach. In this study, poly(lactide-co-glycolide) (PLGA), was the major structural element to be strengthened by a three-dimensional network or 'scaffold' of another biodegradable polymer, poly(propylene fumarate) (PPF). PPF would be crosslinked with a biocompatible vinyl monomer, vinylpyrrolidone (VP). Three different approaches were tested to create dimensionally stable bone plates. First, via in situ crosslinking of PPF in the presence of PLGA. Secondly, by blending of precrosslinked PPF with PLGA. Finally, by simultaneous crosslinking and molding of the PLGA, PPF and VP. These were compared against extruded or compression molded PLGA controls. Results showed that compression molding at room temperature followed by crosslinking under pressure at elevated temperature and subsequently by g-irradiation appeared to yield the most favorable product as judged by swelling, hardness and flexural strength data. The composition of the implant material, PLGA(3):PPF(1):VP(0.7), appeared to be suitable and formed the compositional and procedural basis for in vivo biocompatibility studies.
The Realm of Biopolymers and Their Usage: An Overview
Journal of Environmental Treatment Techniques, 2020
Biopolymers are emerging as an advanced business sector progressively and gained the attention of researchers and industrialists. Polymeric materials are useful due to their flexibility, reusability and toughness nature. These biopolymers can be the amalgamated with various kinds of natural and synthetic materials to synthesize polymeric composites. Such composite materials have comparable properties to oil-based polymers. Biopolymers also play an essential role in the drug and pharmaceutical industry. These can be utilized for industrial purposes, for instance, to regenerate damage, medication administration in addition to regenerative medicine to achieve, low immunogenicity, high pharmacological activity. Several biopolymers are described in this article. There are various mechanisms to produce biopolymers. There are diverse forms of biopolymers that originated from microbes, animals and plants. Biopolymers play a significant role in the chemical and pharmaceutical industries. These are extensively used in medical equipment, cosmetics, confectionery, wastewater treatments, food additives, textiles and in bio-sensing applications. Numerous possible applications, along with the production form of biopolymers, are reviewed in this article.
Structural Features and Biomedical Applications of Biodegradable Polymers
2017
Polymers are a uni que part of our day to day life. In the l ast few years, it has been focused more interest in bi odegradable materials for use in medicine, agriculture, packaging and other s pecific areas. A number of bi o materials may be incorporated into biodegradable polymer materi als, some of them, e.g. fi ber and starch extracted from speci al types of pl ants. It has shown more trust on bi odegradable materi als to create positi ve impact on both economic and environmentally which will overcome the need for synthetic polymer producti on (thus reducing polluti on) at a l ow price. Now a day bi odegradable materials are more demanding in the market and growth is very fast due to its ecofriendl y nature. Subsequently, bio materials are burning topics for research and development in interest. These materials can be categorized as bi odegradable polyesters [poly hydroxy alkanoates, poly (l actic aci d)] and Agro-polymers (protein, starch chitin…)