Event-related synchronization of alpha activity in early Alzheimer's disease and mild cognitive impairment: An MEG study combining beamformer and group … (original) (raw)

In this MEG study, we evaluated the event-related synchronization (ERS) of alpha activity after eye closing in early Alzheimer's disease (AD) and mild cognitive impairment (MCI) patients, without slow MEG pattern. The study involved thirteen AD patients, thirteen MCI patients, and fourteen age-matched controls. It was found that ERS was significantly increased in frontal regions for AD patients compared to controls, suggesting a frontal shift in posterior alpha activity. These initial findings indicate that alpha ERS may be an earlier electromagnetic marker in AD than previously established slow wave activities.