Diagnostic accuracy and pathology of vascular tumours and tumour-like lesions (original) (raw)
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Cytologic findings of malignant vascular neoplasms: A study of twenty-four cases
Diagnostic Cytopathology, 2002
Cytologic characterization of malignant vascular neoplasms (MVN) is difficult due to the wide range of differential diagnoses and sampling errors. The objective of this study was to identify criteria helpful in the cytologic diagnosis of MVN. The clinical presentation and cytomorphologic features of 22 angiosarcomas and two hemangioendotheliomas were analyzed. The criteria evaluated included cellularity, cellular arrangement, cell shape and size, pleomorphism, cytoplasmic borders, nuclear shape and number, chromatin pattern, nucleoli, background, and presence of angioformative structures. A previous history of MVN was noted in 18 of 24 patients. Specimens with epithelioid morphology were more cellular and pleomorphic and contained multinucleated cells. Specimens with spindle morphology were usually less cellular and less pleomorphic. Angioformative structures were identified in 11 of 24 cases. Awareness of features suggestive of MVN is necessary to raise the possibility of vascular origin, which can be confirmed with appropriate immunocytochemical studies. Diagn.
The Importance of Accurate Imaging Diagnosis of a Vascular Anomaly Prior to the Surgical Procedure
Romanian Medical Journal, 2021
The diagnosis of vascular tumors and malformations is usually achieved with clinical history and physical examination. The imaging of these patients has been sufficiently refined to answer pertinent questions when trying to make an accurate differential diagnosis in order to establish an informed treatment plan. The imaging modalities at hand include ultrasound, doppler sonography, magnetic resonance imaging and contrast material enhanced magnetic resonance angiography. We present two cases of different vascular anomalies that were managed according to the clinical aspect, natural history and imaging performed. Moreover, with better understanding of the imaging features, the radiologist has become a key player in the diagnosis and management plan of the vascular anomalies. This is crucial in avoiding misdiagnosis and improper treatment.
Histopathological analysis of soft tissue tumours in a tertiary care hospital
IP innovative publication pvt ltd, 2020
Soft tissue tumours are diverse lesions arising from mesenchymal tissues of the body and present with overlapping clinical and radiological features. Histopathological examination is necessary to arrive at a correct diagnosis. The main objective of the present study is to analyse the trend and pattern of soft tissue lesions in different age groups and sex. Materials and Methods: This is a prospective study carried out in all the specimens which were clinically suspected as soft tissue lesion. The formalin fixed specimens are processed and examined under the microscope. Results: Out of 200 cases examined 97% are benign and 3% are malignant tumours. M ales outnumbered females with 3:1 male to female ratio. More number of cases were seen in 31-40 years of age group (30%) followed by 21-30 years (27%). In the benign category, majority were lipomatous tumours (87.6%) followed by the blood vessel tumours (7.2%). Malignant tumours were seen only in males. Conclusion: Histopathology is the gold standard tool for diagnosis and it needs thorough and very careful examination to arrive at an accurate diagnosis.
European Radiology, 2017
Purpose To evaluate the efficacy and safety of percutaneous endovascular biopsy (PEB) in intravascular filling-defect lesions (IVLs) of the great vessels. Material and methods We retrospectively reviewed 19 patients (age 65 ± 12 years), 11 men and eight women, who underwent PEB for IVLs, between March 2004 and November 2014. All PEBs were performed for early diagnosis and/or characterization of the IVL, or in case of reasonable doubt about the IVL nature. Pre-intervention imaging workup included CT, MRI and/or PET-CT. PEBs were obtained with a 7F biopsy forceps device. Clinical profile, procedure technical success and safety, and clinical success were evaluated. Results PEB was technically successful in all patients (mean of two samples per IVL). No intra-or post-procedural complications were reported. Histopathological analysis provided a diagnosis in all PEBs with a clinical success of 100%. Of the 19 IVLs, 14 were malignant (74%). The most frequent malignant lesion observed was leiomyosarcoma (29%). Benign lesions (26%) included three thrombi (pulmonary artery) and two myxomas. Conclusion PEB is a safe and efficient procedure providing the most effective technique to obtain a tissue sample of high diagnostic quality, which serves to establish early diagnosis in patients with suspected malignant lesions. Key Points • Intravascular filling-defect lesions are related to both benign conditions and malignant tumours. • Endovascular biopsy is indicated in case of doubt about intravascular lesion nature. • Percutaneous endovascular biopsy is a safe technique. • Endovascular biopsy provides tissue samples leading to correct histopathological analysis. • Percutaneous endovascular biopsy provides early diagnosis of malignant intravascular lesions.
Diferential Diagnoses of Angiokeratomas
2020
Angiokeratomas (AK) are probably the vascular lesions that induce more confusion in the literature. The most accepted classification of AK was performed by Imperial and Helwig[1], and they divide these lesions into five classical types: Mibelli’s AK, Fordyce’s AK, corporis diffusum AK, circumscribed naeviforme AK and solitary or multiple adquired angiokeratomas. Nevertheless, in the clinical practice, is not unusual to see AK type lesions associated to different types of vascular anomalies, and these lesions have difficult handling. In ISSVA classification AKs have been included as vascular anomalies provisionally unclassified. We perform the differential diagnoses of AKs and according to clinical picture, histopathological aspect, immunohistochemical markers and radiological findings proposed to divide AKs mainly in two groups. Primary AKs are the classical types. The new inmunohistochemical findings suggest that these lesions might be included as mixed capillary-lymphatic malforma...
Cureus, 2022
Background Cutaneous vascular malformations and tumors comprise a vast group of conditions with variable clinical presentations. It is imperative to differentiate them from nonvascular lesions and from each other as their management and prognosis differ significantly. There is only sparse literature on dermoscopic features of various vascular malformations and tumors, especially from India. Aim We aimed to retrospectively study the dermoscopic findings of various vascular malformations and tumors based on their dominant vascular dermoscopic feature. Method All the vascular malformations and tumors for which clinical details and clinical and dermoscopic images were available were included in the analysis. The dominant vascular feature(s) was defined as a single or combination of two or more vascular features (in case a single vascular feature does not satisfy the criteria) that constitute more than 75% of the lesions' vascular features. These included red, purple, blue, black (or any combination) dots, globules, lacunae, structureless area, linear, linear irregular, hairpin, comma, and arborizing vessels. Results A total of 52 patients with 68 vascular lesions (22 vascular malformations and 46 vascular tumors) were analyzed. Port-wine stain showed linear irregular vessels with sharp border with or without intervening white structureless area; unilateral nevoid telangiectasia had red dots and globules; angiokeratoma displayed red, reddish-purple to brown lacunae; blue color was seen in venous and glomuvenous malformation and venous lake; a mixed pattern was noted in infantile hemangioma and verrucous hemangioma; a red to reddish-white structureless area was observed in pyogenic granuloma and cherry angioma, and a subungual ill-defined pink structureless area was spotted in subungual glomus tumor. Conclusion The dermoscopic features observed in various vascular lesions may overlap; however, the dominant dermoscopic feature along with its color may point to the diagnosis.
Seminars in Plastic Surgery, 2014
Vascular anomalies can be broken down into two major categories: tumors and malformations. These clinical entities are extremely different, but often confused, as evidenced by the history and medical literature. A thorough medical history and physical exam is essential when it comes to defining any vascular anomaly. There are several different vascular tumors, but infantile hemangiomas are the most common. Others tumors that will be discussed include tuft angiomas, pyogenic granulomas, angiosarcomas, and kaposiform hemangioendotheliomas. Management of vascular tumors depends on their medical history, diagnosis, and most importantly their location.
Histopathological diagnosis of cutaneous vascular sarcomas
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2010
Cutaneous sarcomas represent a heterogeneous group of mesenchymal lesions. This study investigates the histopathological and immunohistochemical features in different cases of angiosarcoma and Kaposi's sarcoma (cutaneous vascular sarcomas), which are representative for medical practice. The clinical-histopathological-immunohistochemical correlations render possible the differential diagnosis and a proper treatment can be applied to obtain a favorable prognosis.
Diagnostic surgical pathology: the importance of second opinion in a developing country
2004
OBJECTIVE To review the cases sent to the section of histopathology, Aga Khan Universty (AKU) for second opinion and see whether there are significant differences in the original outside diagnosis and the subsequent diagnosis submitted by us. METHODS A retrospective study of all consecutive cases for second opinion in the form of paraffin blocks from 1st Novemver 2001 to 31st July 2002. The primary submitted diagnosis in each case was compared with the subsequent AKU diagnosis. RESULTS The study included a total of 381 cases. However, in 45 cases (11.81%), initial histopathological diagnosis was not provided. Out of the remaining 336 cases, there were differences between the original diagnosis and the subsequent AKU diagnosis in 120 cases (35.71%). Out of these 120 cases, immunohistochemistry was performed in 65 cases (54.16%) only. CONCLUSION In a developing country like Pakistan, where few laboratories are equipped to function as modern histopathology units, second opinion on diff...