Functional and Biochemical Alterations of the Medial Frontal Cortex in Obsessive-Compulsive Disorder (original) (raw)

Abstract

The medial frontal cortex (MFC), including the dorsal anterior cingulate and the supplementary motor area, is critical for adaptive and inhibitory control of behavior. Abnormally high MFC activity has been a consistent finding in functional neuroimaging studies of obsessive-compulsive disorder (OCD). However, the precise regions and the neural alterations associated with this abnormality remain unclear.

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