Thirty years' experience with gastrinoma (original) (raw)

Over a 30-year period , 40 patients with gastrinoma have been studied. Fifteen of the 19 survivors have lived 10 to 28 years following surgical treatment. Recent multiple endocrine studies in the long-term survivors have verified the clinical importance of including at least prolactin, parathormone, and catecholamine levels in addition to gastrin and calcium in every patient whose risk of other endocrine adenomas increases with time. Five-year survival was 62.5%, and 10-year, 47.5%. The absence of gross tumor at operation, origin within the submucosa of the duodenum or antrum, or proof of hyperparathyroidism favorably influenced long-term survival, regardless of the type of surgical procedure. Survival was improved following removal of a rare solitary tumor or combined aggressive tumor removal, hemipancreatectomy, and total gastrectomy for extensive disease.