R -citalopram functionally antagonises escitalopram in vivo and in vitro : evidence for kinetic interaction at the serotonin transporter (original) (raw)

The S-enantiomer of R,S-citalopram, increases inhibitor binding to the human serotonin transporter by an allosteric mechanism. Comparison with other serotonin transporter inhibitors

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The interaction of escitalopram and R-citalopram at the human serotonin transporter investigated in the mouse

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The Pharmacology of Citalopram Enantiomers: The Antagonism by R-Citalopram on the Effect of S-Citalopram*

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An allosteric binding site at the human serotonin transporter mediates the inhibition of escitalopram by R-citalopram: Kinetic binding studies with the ALI/VFL–SI/TT mutant

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Allosteric effects of R- and S-citalopram on the human 5-HT transporter: Evidence for distinct high- and low-affinity binding sites

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Differences in the dynamics of serotonin reuptake transporter occupancy may explain superior clinical efficacy of escitalopram versus citalopram

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Higher serotonin transporter occupancy after multiple dose administration of escitalopram compared to citalopram: an [ 123 I]ADAM SPECT study

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In vivo imaging of serotonin transporter occupancy by means of SPECT and [ 123 I]ADAM in healthy subjects administered different doses of escitalopram or citalopram

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Effects of Acute and Long-Term Administration of Escitalopram and Citalopram on Serotonin Neurotransmission: an In Vivo Electrophysiological Study in Rat Brain

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Characterization of an allosteric citalopram-binding site at the serotonin transporter

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Mutational Mapping and Modeling of the Binding Site for (S)-Citalopram in the Human Serotonin Transporter

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High- and low-affinity binding of S-citalopram to the human serotonin transporter mutated at 20 putatively important amino acid positions

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[ 3 H]Citalopram Binding to Brain and Platelet Membranes of Human and Rat

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Biochemical effects and drug levels in rats after long-term treatment with the specific 5-HT-uptake inhibitor, citalopram

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Improved Potency of Escitalopram on the Human Serotonin Transporter

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Effects of citalopram infusion on the serotonin transporter binding of [11C]DASB in healthy controls

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Structure-activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the serotonin transporter

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In vivo steady-state pharmacokinetic outcome following clinical and toxic doses of racemic citalopram to rats

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The Selective Serotonin Reuptake Inhibitor Citalopram Induces the Storage of Serotonin in Catecholaminergic Terminals

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R-citalopram prevents the neuronal adaptive changes induced by escitalopram

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Review of pharmacokinetic and pharmacodynamic interaction studies with citalopram

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Affinity modulation of [3H]imipramine, [3H]paroxetine and [3H]citalopram binding to the 5-HT transporter from brain and platelets

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Allosteric modulation of the effect of escitalopram, paroxetine and fluoxetine: in-vitro and in-vivo studies

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Selective inhibition of the serotonin transporter in the treatment of depression: Sertraline, fluoxetine and citalopram

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Affinity modulation of [H]imipramine, [H]paroxetine and [H]citalopram binding to the 5HT transporter from brain and platelets

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Escitalopram versus citalopram: the surprising role of the R-enantiomer

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Augmentation with a 5-HT1A, but not a 5-HT1B receptor antagonist critically depends on the dose of citalopram

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Transport mechanisms for the antidepressant citalopram in brain microvessel endothelium

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Antidepressants Targeting the Serotonin Reuptake Transporter Act via a Competitive Mechanism

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Inhibitory and regulatory binding sites on the rat brain serotonin transporter: molecular weight of the [3H]paroxetine and [3H]citalopram binding proteins

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Desensitisation of 5-HT autoreceptors upon pharmacokinetically monitored chronic treatment with citalopram

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