Macular and retinal nerve fiber layer analysis of normal and glaucomatous eyes in children using optical coherence tomography (original) (raw)
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Srpski arhiv za celokupno lekarstvo, 2017
Introduction/Objective. Evaluation of the optic nerve head (ONH) is an inevitable procedure in the diagnosis of glaucoma. One of the most common imaging techniques for a quantitative assessment of the topography of the ONH is the Heidelberg retinal tomography II (HRT II). The aim of this study was to determine quantitative stereometric parameters of the ONH by using the HRT II and to investigate any damage of neuroretinal rim in children with suspected glaucoma and compared these data with the group of adults with suspected glaucoma. Methods. This comparative study included 167 (167 eyes) children aged 11?3 years with suspected juvenile glaucoma and 175 adult participants (175 eyes), aged 60?3 years, also with suspected glaucoma, examined between January 2013 and April 2014. Optic nerve head topography and retinal nerve fiber layer thickness measurements were assessed using a HRT II. Results. Data analysis in this study showed that the average mean values for children/adults were: d...
Clinical Ophthalmology, 2013
To assess the difference in retinal nerve fiber layer (RNFL) and optic disc algorithms between glaucomatous and normal Arab subjects using optical coherence tomography (OCT). Methods: RNFL thickness and optic disc parameters were obtained in 65 patients aged 50.1 ± 7.7 years. Percentage differences in all parameters were calculated and analyzed between groups. Results: The mean RNFL thickness around the disc and at all quadrants was significantly thinner in glaucomatous eyes than in normal eyes (P , 0.01). The greatest decrease in RNFL thickness was observed at the inferior (39.5%) and superior (39.3%) quadrants and at 1 o'clock (43%) and 5 o'clock (40%) hour sectors. Significant differences were observed between glaucomatous and control eyes in all disc parameters (P , 0.005) assessed. The disc area, cup area, mean cup/disc ratio, and vertical and horizontal cup/disc ratios were significantly larger (P , 0.01), whereas the vertical integrated rim area, horizontal integrated rim width, and rim area were significantly smaller (P , 0.001) in glaucomatous eyes than in normal eyes. Conclusion: Stratus OCT is still a valuable tool in the diagnosis of early glaucoma changes and, as such, its use should be encouraged in glaucoma clinics in Saudi Arabia. The best OCT parameters for detecting early glaucoma change were RNFL thickness in the inferior, superior, and 1 o'clock hour sector; the cup area; and the vertical integrated rim area of the optic disc.
Evaluation of Peripapillary and Macular Nerve Fiber Layer Thickness in Paediatric Glaucoma Suspects
Journal of Nepal Paediatric Society
Introduction: Glaucoma patients are known to have optic disc cupping, leading to loss of retinal ganglion cell axons. This peripapillary nerve thinness is known to be associated with glaucoma in adult patients. Hence, we intended to evaluate the peripapillary and macular nerve fiber thickness in eyes of pediatric glaucoma suspects using spectral domain optical coherence tomography (OCT). Methods: This cross-sectional analytical study included 44 eyes of 22 paediatric glaucoma suspects, who were compared with 40 eyes of 20 normal paediatric eyes. Pearson correlation coefficients were calculated to assess the relations between the peripapillary retinal nerve fiber layer (RNFL) thickness and ganglion cell complex (GCC). Receiver Operating Characteristics (ROC) curve was plotted for OCT parameters in both the groups along with area under the curve (AUC) calculation. P values < 0.05 were considered as statistically significant. Results: We found the RNFL to be thickest in the superior...
American Journal of Ophthalmology, 2012
PURPOSE: To determine the normative values of the peripapillary retinal nerve fiber layer (RNFL), macular thickness, and macular volume in healthy children using spectral-domain optical coherence tomography (SD-OCT) and analyze the correlation of such values with age, refraction error, and biometric measurements. • DESIGN: Observational case series. • METHODS: This institutional study involved 107 eyes from 107 healthy pediatric patients (54 female, 53 male) with ages between 6 and 16 years. After the biometric measurements and refractive error values (in spherical equivalent) of the cases were obtained, the peripapillary RNFL, macular thickness, and macular volume values were calculated using the Spectralis OCT device. • RESULTS: Among the study group, with an average age of 10.46 ؎ 2.94 years, the average axial length (AL) was 23.33 ؎ 0.89 mm; the average spherical equivalent (SE) value was ؊0.27 ؎ 0.99 diopter. The average peripapillary RNFL thickness was 106.45 ؎ 9.41 m; the average macular thickness was 326.44 ؎ 14.17 m; and the average macular volume was 0.257 ؎ 0.011 mm 3 . The aforementioned OCT measurements were not significantly correlated with age, SE, or AL values (P > .05 for all). • CONCLUSIONS: This study reports SD-OCT findings among healthy pediatric cases. SD-OCT can be reliably used for pediatric patients because of its short exposure time and high degree of image resolution. (Am J Ophthalmol 2012;153:552-559.
Relationship between GDx VCC and Stratus OCT in juvenile glaucoma
Eye, 2009
Purpose To compare the ability of scanning laser polarimetry (GDx VCC) and optical coherence tomography (OCT) to discriminate eyes with juvenile glaucoma from normal eyes and to assess the relationship between their parameters. Methods A total of 24 glaucomatous eyes of 24 patients and 24 normal eyes were enrolled. The age range of the patient was 11-40 years with a mean age of 25.1 ± 8.2 years. Contol groups consisted 24 eyes of 24 individuals without glaucoma with a mean age of 33.2 ± 8.2 years. All subjects underwent a full ophthalmic examination, automated perimetry, GDx VCC, and OCT. Correlation coefficients between the parameters of OCT and GDx VCC were calculated. We calculated the area under the receiver operating characteristic curve (AROC) for the main parameters of GDx VCC and OCT.
Oftalmologicheskiĭ zhurnal, 2021
To determine the concordance of retinal nerve fiber layer (RNFL) thickness in glaucomatous and normal fellow eyes and also to compare it with normal individuals using optical coherence tomography (OCT). Material & method. An observational cross-sectional study including 73 primary open angle glaucoma cases and 73 normal individuals not having primary open angle glaucoma (POAG) was done. RNFL thickness of both eyes was measured using OCT by fast RNFL thickness protocol. Average RNFL thickness, quadrantic that is inferior, superior, nasal and temporal, and sectoral RNFL thickness was evaluated. The values were compared among the fellow normal eyes and glaucomatous eyes of the same patient and also with the eyes of individuals not having glaucoma. Results. The average RNFL thickness for normal eyes was 90.65±15.04 μm, glaucomatous eyes was 76.83 ± 14.02 μm and fellow eyes of glaucomatous patients was 82.06±14.60 μm. A statistically significant difference was seen both between non glaucomatous and glaucomatous group and also between glaucomatous and fellow eyes of glaucomatous group. (p<0.001) Conclusion. Symmetry of RNFL defects was seen between glaucomatous patients and their fellow eyes corresponding with the pattern of early glaucomatous damage.
OCT for glaucoma diagnosis, screening and detection of glaucoma progression
British Journal of Ophthalmology, 2013
Optical coherence tomography (OCT) is a commonly used imaging modality in the evaluation of glaucomatous damage. The commercially available spectral domain (SD)-OCT offers benefits in glaucoma assessment over the earlier generation of time domain-OCT due to increased axial resolution, faster scanning speeds and has been reported to have improved reproducibility but similar diagnostic accuracy. The capabilities of SD-OCT are rapidly advancing with 3D imaging, reproducible registration, and advanced segmentation algorithms of macular and optic nerve head regions. A review of the evidence to date suggests that retinal nerve fibre layer remains the dominant parameter for glaucoma diagnosis and detection of progression while initial studies of macular and optic nerve head parameters have shown promising results. SD-OCT still currently lacks the diagnostic performance for glaucoma screening.