Development of an in vitro technique for measuring elastic properties of vocal fold tissue (original) (raw)

Journal of speech and hearing research, 1988

Abstract

The purpose of this investigation was to develop an in vitro technique for measurement of elastic properties of isolated vocal fold tissue. Larynges were excised from anesthetized dogs, immediately submerged in a Krebs-Ringer solution, and aerated with 95% oxygen and 5% carbon dioxide. The tissue was maintained in the aerated electrolyte solution throughout the experiment. The vocalis muscle was carefully dissected, with attachments to the arytenoid and thyroid cartilages maintained. The preparation was then subjected to isometric (constant length) force-elongation measures, which were converted to stress-strain values. Stage I of the investigation identified the dog model with the least intrastudy variability relative to the age, sex, and breed of the research animal, as well as to the effects of curare. Stage II investigated the effects of different instrumentation, definitions of reference length, methods of elongation, and effects of electrical stimulation. Once the procedure ha...

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