Molecular imaging of active mutant L858R EGF receptor (EGFR) kinase-expressing nonsmall cell lung carcinomas using PET/CT (original) (raw)

2011, Proceedings of the National Academy of Sciences

AI-generated Abstract

The EGF receptor (EGFR) signaling pathway plays a critical role in the development of nonsmall cell lung carcinomas (NSCLC), especially in tumors with activating mutations. This study demonstrates that PET imaging with [18F]F-PEG6-IPQA can effectively distinguish between H3255 NSCLC xenografts expressing the L858R mutant EGFR and other variants. The findings suggest potential for using this imaging technique to select NSCLC patients for targeted therapies using EGFR kinase inhibitors, enhancing personalized treatment approaches.

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