Well-differentiated abdominal liposarcoma: experience of a tertiary care center (original) (raw)
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Journal of Orthopaedic Science, 2018
Background and objectives: Liposarcoma (LPS) is a malignant mesenchymal tumor and the most common soft tissue sarcoma. Four different subtypes are described: well differentiated (WD) LPS or atypical lipomatous tumor (ALT), dedifferentiated (DD) LPS, myxoid LPS, and pleomorphic LPS (PLS). The objective of the study was to investigate prognostic factors and clinical outcome of liposarcoma. Methods: We retrospectively examined the clinico-pathological features of a series of 307 patients affected by Liposarcoma at a mean follow-up of 69 months (range 6e257). ALT/WD LPS were analyzed separately. The influence of site, size, type of presentation, grading, histotype and local recurrence on local and systemic control and survival was assessed. Results: The statistical analysis indicated that only surgical margins represented a significant prognostic factor for local recurrence in ALT/WD LPS (P ¼ 0.0007) and other subtypes of LPS (P ¼ 0.0055). In myxoid, PLS and DD LPS, significant prognostic factors for metastasis free survival (MFS) were surgical margins (P ¼ 0.0009), size of the tumor (P ¼ 0.0358), histology (P ¼ 0.0117) and local recurrence (P ¼ 0.0015). In multivariate analysis, surgical margins (0.0180), size (0.0432) and local recurrence (0.0288) correlated independently with MFS. Margins (P ¼ 0.0315), local recurrence (P ¼ 0.0482) and metastases (P < 0.0001) were prognostic factors for overall survival (OS). Conclusion: Marginal surgery can be an accepted treatment for ALT/WD LPS. In other liposarcoma subtypes (Myxoid, DD, PLS) wide or radical surgery is recommended as the margins significantly influence local recurrence-free survival (LRFS), metastasis-free survival (MFS) and overall survival (OS). Local recurrence and metastases were significant prognostic factors for OS.
Atypical Lipomatous Tumor/Well Differentiated Liposarcoma: a Borderline Malignancy Tumor
Modern Medicine, 2016
Controversy exists with regard to the nomenclature, treatment and outcome of a group of well-differentiated lipomatous tumors sometimes labelled as atypical lipomatous tumors. For elimination of inadequate or excessive treatment it has been advocated that the term well-differentiated liposarcomas be retained for retroperitoneal/mediastinal tumors and atypical lipomatous tumors for the rest of the sites. The most important prognostic factor for ALT/WD liposarcoma is anatomic location, overall mortality ranging from 0% for ALT of the extremities to more than 80% for WD liposarcomas occurring in the retroperitoneum if the patients are followed up for 10-20 years. Primary treatment of ALT/WD liposarcoma is represented by a complete, preferably wide-margin surgical resection. The role of radiation therapy for atypical lipomatous tumors/well-differentiated liposarcomas is still unclear. Despite the side effects of postoperative radiation therapy it has been shown that in patients with positive surgical margins postoperative RT in doses over 64Gy, improves local control.
Omental Well-Differentiated Liposarcoma: US, CT and MR Findings
International journal of biomedical science : IJBS, 2009
Liposarcomas are the most common of sarcoma tumours, they are usually located in the lower limbs, retroperitoneum, or abdominal cavity; up to date, only a few cases of omental liposarcoma with different histotype have been described. We present a case of omental well-differentiated liposarcoma and discuss imaging findings on ultrasound, computed tomography, and magnetic resonance to differentiate omental liposarcomas from other abdominal tumour entities.
Primary liposarcoma of the stomach
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2013
Sarcomas represent less than 1% of adult solid malignancies and are rarely seen in the gastrointestinal tract. Here, we report a 59-year-old female with a well-differentiated liposarcoma of the stomach. This is the first case in the literature in which endoscopic ultrasound proved to be a diagnostic tool for gastric liposarcoma.
Prognosis of Liposarcoma Patients in Modern ERA: Single-Center Experience
South Asian Journal of Cancer
Objective Liposarcomas are relatively rare tumors. Prognostic and predictive factors and treatment options are limited. We herein presented our 10-year experience with liposarcomas. Materials and Methods Adult patients with liposarcoma treated between 2005 and 2015 in our center were included. Demographic and clinicopathologic features of patients were retrieved from patient files. Statistical Analyses Outcomes in terms of disease-free survival (DFS) and overall survival (OS) were assessed along with potential prognostic factors using Kaplan–Meier analyses. Results A total of 88 patients were included. The median age was 52. Rates of well-differentiated (WDLS), dedifferentiated (DDLS), myxoid (MLS), and pleomorphic liposarcomas (PLS) were 42, 9.1, 37.5, and 4.5%, respectively. Only 10% of patients had high-grade tumors and 93% had localized disease. Ninety-six percent of patients (n = 84) underwent surgery. Adjuvant chemotherapy was delivered to 16 patients. The most common regimen ...
Spectrum of liposarcomas-a study of 106 cases
Journal of Ayub Medical College, Abbottabad : JAMC
Liposarcoma is a malignant tumour that arises in fat cells in deep soft tissue. This study was conducted to access the spectrum of liposarcomas This descriptive study was conducted at Armed Forces Institute of Pathology (AFIP), Rawalpindi from 1st January 2008 to 31st December, 2012 and included all the cases diagnosed as liposarcomas. Records of the malignant tumors of soft tissue that presented during this period were analysed and out of this spectrum of liposarcomas were studied. A total of 19367 malignant tumours were diagnosed during study period. Out of these, 615 were malignant soft tissue tumours. Out of these 106 cases were liposarcoma with an overall frequency of 0.54% of the malignant neoplasm and 17.24% of soft tissue sarcomas .The age ranged from 26-85 years. Out of these 106 cases 77 were male and 29 were female with a male to female ratio of 2.6:1. The most common tumour seen was pleomorphic liposarcoma (42.5%) followed by myxoid liposarcoma (22.6%), dedifferentiated ...
SAS Journal of Medicine
Liposarcomas are rare soft tissue tumors that arise from adipose tissue. They account for 1% of all malignancies and 15% to 20% of soft tissue sarcomas. Between January 2010 and January 2020, we reported 21 cases of Liposarcomas detected at the university hospital Mohamed VI of Marrakech's anatomical pathology department. The average age is 50, with a male majority. The average length of consultation was two years. The most revealing indication is tumefaction of the soft tissue. Most of the lesions were concentrated in the lower extremity. The preferred seat for these malignancies is the thigh. The X-ray was used on 21 patients, the echography was used on 16 patients, and the computed tomography was used on 15 patients. There have been 12 cases of magnetic resonance imaging and two cases of Doppler echography for two patients. The well differentiated Liposarcoma is the most common histologic sub-type (52%), followed by myxoid Liposarcoma (28%). 95% of patients had surgery, 90% o...