Association of Trypanosoma cruzi infection with risk factors and electrocardiographic abnormalities in northeast Mexico (original) (raw)
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American Journal of Tropical Medicine and Hygiene, 2010
Trypanosoma cruzi prevalence in triatomines and risk factors associated to the presence of the insect were studied in 990 rural houses in the southern region of the State of Mexico, Mexico. In each house, triatomines were collected, and information related to house construction material was obtained. T. cruzi infection was diagnosed in all triatomines. A primary screening was performed using 2 × 2 contingency tables of exposure variables. All variables with P ≤ 0.20 were analyzed by logistic regression. Triatomines (N = 125) were collected from 822 houses and analyzed for T. cruzi infection. Triatoma pallidipennis (97.4%) and Triatoma dimidiata (2.6%) were identified in 52.1% of the localities and in 6.1% of the houses. Infection was found in 28.0% of triatomines, from which 28.9% were nymphs. Factors associated with triatomine infestation were flooring construction material (dirt floor: odds ratio [OR], 10.05; 95% confidence interval [CI], 5.31-18.04; P = 0.0001), house rooms (at least three rooms: OR, 2.04; 95% CI, 1.07-3.86; P = 0.028), and ceiling construction material (cardboard lamina tile: OR, 6.84; 95% CI, 1.49-31.31; P = 0.013). This study shows T. cruzi circulation in triatomines in the area of study, and because triatomines are adapted for living and reproducing in the domestic environment, there is a potential risk of Chagas disease transmission to humans. Also, we can conclude that the construction materials and house inhabitants are risk factors of triatomines infestation.
Annals of parasitology, 2015
The Yucatan Peninsula of Mexico is endemic with Chagas disease. The main vector responsible for Trypanosoma cruzi transmission is Triatoma dimidiata which is abundant in domestic, peridomestic and sylvan cycles. The abundance of vectors favours T. cruzi transmission and is a high risk for developing chronic chagasic cardiomyopathy (CCC). In the past 10 years, little information was available on parasite seroprevalence and the prevalence of CCC in the Yucatan Peninsula. In the present work, we studied two Mayan communities with a high abundance of T. dimidiata and a random serial sample of 233 patients with an altered electrocardiogram or cardiac failure admitted to the Regional Hospital. A homemade enzyme-linked immunosorbent assay and indirect immunofluorescence standardized techniques were used to detect anti-T. cruzi IgG. In addition, Mayan volunteers were monitored by electrocardiography. In the Mayan communities, 4.8% (3/63) subjects were positive for T. cruzi antibodies none o...
2001
Trypanosoma cruzi infection in central Mexico has not been fully documented, yet some data suggest its presence. In this work, sera from 211 subjects living in the state of Morelos and at risk of T. cruzi infection due to their living in contact with the vector were analyzed for the presence of antibodies to a total antigen extract of a Mexican isolate of T. cruzi. A seropositivity of 20% was demonstrated by both an enzyme-linked immunosorbent assay and Western blotting. Furthermore, parasites were isolated from five seropositive individuals, and these were genetically characterized as T. cruzi by multilocus enzyme electrophoresis. A case-control electrocardiographic study was conducted that included the seropositive individuals and twice as many seronegative controls living in the same area. A significant correlation was found between seropositivity and electrocardiographic alterations. These findings have important implications for perception of the prevalence of Chagas' disease in Mexico. Moreover, the presence of this disease in rural communities rapidly transforming into urban ones might have important epidemiologic consequences.
American Journal of Tropical Medicine and Hygiene, 2013
We studied a small rural community of 411 inhabitants localized in the state of Campeche in the Yucatan Peninsula, Mexico. In 44 collected triatomines captured inside the houses, human feeding source was revealed in 23 of 44 (52%) samples, and chicken feeding source was revealed in 16 of 44 (36%) samples. In a set of 29 triatomines, mouse was the feeding source in 13 (44%) samples, and dog was the feeding source in 7 (24%) samples. Infection index with Trypanosoma cruzi in collected triatomines was 38%, and all parasites belonged to discrete type unit I. Inhabitants referred high contact with triatomine's bite in 60 of 128 (47%) samples, but seroprevalence was 2.3% (3/128). Evidence of electrocardiographic alteration compatible with Chagas disease was observed only in one asymptomatic seropositive subject. In conclusion, Triatoma dimidiata in this region are preferentially infected with T. cruzi I and feed on human beings with relative high frequency, but seroprevalence and Chagas disease in humans is relatively low.
Avances en Ciencias e Ingeniería, 2014
Chagas disease is a prevalent and potentially fatal parasitic infection that affects millions of people, especially in Latin America. The causative agent of the disease is the protozoan Trypanosoma cruzi, transmitted mainly by blood-sucking insect vectors of the subfamily Triatominae. The objective of this study was to analyze the infection by Trypanosoma cruzi in the vector Triatoma dimidiata in a rural area of Southern coastal Ecuador. Triatominae searches were carried out in peridomestic habitats of households located in Bajada de Chanduy, a rural village in the border between Santa Elena and Guayas provinces. Feces and intestinal contents were extracted from the insects and observed in the microscope for the presence of mobile trypanosomes. Approximately 72% of the insects analyzed were infected with trypanosomes. This percentage reflects the occurrence of active foci of T. cruzi and the potential risk that this poses for people living in rural villages in the study area. The trypanosomes that were found infecting the triatomine bugs will be molecularly identified and a study of the genetic variability of the population of T. dimidiata collected at the study site will be carried out in the future. The results of all these analyses will provide a better understanding of the epidemiology of Chagas disease in rural Ecuador, which is an essential step in the development of control and prevention strategies for the transmission of this pathogenic parasite.
American Journal of Epidemiology, 1991
The reduction of domiciliary infestation by insect vectors, the key to controlling Chagas' disease, depends on identification of housing features associated with infestation. In this study, log-linear modeling was used to reanalyze data collected in 1964-1968 from 371 houses on characteristics potentially associated with infestation by the vector Triatoma dimidiata in a Costa Rican town with endemic Chagas' disease. A possible increased risk of infestation was observed for houses with a dirt floor (as compared with houses with another floor type) and for houses in poor sanitary condition (as compared with houses in good sanitary condition). A new risk factor for house infestation, the presence of roof tiles, was identified; the odds of infestation for houses with a tile roof were 2.4 times greater than the odds for houses with a galvanized metal roof. This significantly increased risk is probably due to the harboring of T. dimidiata in stacks of spare tiles next to house walls rather than to the tile roofs themselves. Am J Epidemiol 1991 ;133:740-7. epidemiologic methods; housing; insect vectors; risk factors; socioeconomic factors; Triatomidae; Trypanosoma cruzi; trypanosomiasis, South American Chagas' disease (American trypanosomiasis) has been reported from every country in Central and South America, as well as from Mexico, and sporadically from the United States. It adversely affects the health, welfare, and productivity of large groups of people, especially those of low socioeconomic status in agricultural regions (1-3). Recent studies estimate that 19-24 million people are infected with the etiologic agent Trypanosoma cruzi and that about 65 million people are currently exposed (1,4, 5). These represent substantial increases from the 1960 World Health Organization estimates of 7 million and 35 million, respectively (3). This corresponds to a current prevalence of 6-8 percent in Latin America, although prevalence may exceed 40 percent in endemic areas (6, 7). The parasitic protozoan T. cruzi has a
Current prevalence and risk factors related to Chagas disease in Bolivia
Humboldt kolleg Ibarra 2019, 2019
Chagas disease (CD) caused by Trypanosoma cruzi, is a major health problem in Bolivia. In this study, we have assessed the prevalence and the risk of infection by T. cruzi in nine Bolivian departments. The overall average seroprevalence was 19.5% (2-32%) being higher in women between 11-20 years old. The T.cruzi genetic lineages infecting humans was 43.4% TcI; 45.4% TcV, 8.5% TcII and 2.7% for TcV and TcII. T. cruzi infection was detected in 49.1% of the 1,671 Triatoma infestans captured within houses, the majority (65%) made of bricks. Among these, 39.5% were TcI, 52.1% TcV, and 8.4% TcII. The assessment on the knowledge about the disease and the etiological agent revealed that 57% of teachers and health workers are aware of the parasite and 64% of the students receive information about CD, among which, 82% were able to recognize triatomines.