Adenomyoepithelioma of the breast, presenting as a cancer (original) (raw)
Related papers
Adenomyoepithelioma of the breast as a diagnostic problem
2009
Adenomyoepitheliomas are extremely rare breast tumours that were not described and classified until after the1990s. They are characterised by biphasic proliferation of ductal and myoepithelial cells organised in ribbon-like, solid, tubular or lobular arrangements. During years adenomyoepithelioma represent poorly understandable diagnostic entity which biological behaviour cannot be always predicted on the basis of the cytological characteristics and histological architecture. Diagnosis by clinical examination and imaging studies remains difficult, and frozen sections of selected areas can potentially be misdiagnosed as malignant. In this study, we present a case of a breast adenomyoepithelioma in 68-year-old woman. The diagnosis was made with immunohistochemistry following a surgical excision.
Case Report Adenomyoepithelioma of breast Adenomyoepithelioma Of Breast : Report Of A Rare Case
2016
Benign adenomyoepithelioma of the breast is a rare tumor characterized by biphasic proliferation of both an inner layer of epithelial cells and a prominent peripheral layer of myoepithelial cells. This entity may rarely progresses to a more malignant state or gives rise to metastasis. Accurate diagnosis and close follow up is essential for proper treatment of these tumors. We report a 15 year old girl who presented with large lump in the breast which was clinically mistaken for a giant fibroadenoma of breast. No nodes were palpable. On gross examination, a large lump 11x11x8 cm was noted which was well circumscribed, solid on cut section. On histopathologic examination the diagnosis of adenomyoepithelioma was made which was further supported by immunohistochemistry findings.
Adenomyoepithelioma of the Breast: A Report of 3 Cases
American Journal of Case Reports, 2022
Objective: Rare disease Background: Breast adenomyoepithelioma is a rare benign breast tumor characterized by a biphasic proliferation of epithelial and myoepithelial cells with variable clinical and diagnostic features. Establishing the diagnosis, determining optimal therapy, and predicting outcome are problematic because of the rarity of this entity. There have been only 2 large series of adenomyoepitheliomas of the breast, reported by Tavassoli and Rosen, which included 27 and 18 patients, respectively. In this report, we present 3 cases of breast adenomyoepithelioma. Case Reports: Herein, we report 3 cases of breast adenomyoepithelioma. The first case is of a 64-year-old woman who was found to have right breast microcalcification on a screening mammogram. The second case is of a 74-year-old woman who had a right breast mass. These 2 patients were managed by wide local excision. Postoperative microscopic examination revealed adenomyoepithelioma. The third case is of a 49-year-old woman with bilateral saline breast implants who presented with a left breast mass. A core needle biopsy was done and revealed adenomyoepithelioma associated with usual ductal hyperplasia and ductal carcinoma in situ. Conclusions: Breast adenomyoepithelioma is a rare condition that can pose diagnostic challenges due to variable imaging presentations, necessitating percutaneous core biopsy for initial diagnosis. Correct diagnosis is usually possible only on excisional biopsy and confirmed by demonstrating the biphasic nature of the tumor by IHC. Clinical suspicion coupled with utilizing both radiological and histopathological facilities can aid in the accurate diagnosis and management. For the most part, they are considered to be benign, but they can locally recur.
Adenomyoepithelioma of the breast with unusual confounding diagnostic feature: a case report
Journal of Medical Case Reports
Background Adenomyoepithelioma of the breast is an uncommon subtype of breast neoplasm that occurs in adults over a wide age range but most commonly in middle-aged and older adults. It usually presents as a solitary palpable mass or is detected on breast radiographic images. Histologically, it is a biphasic tumor with proliferation of both the epithelial and myoepithelial components of the glands, with variable types of tissue metaplasia. Case presentation A 64-year-old Saudi woman who underwent regular breast screening (mammogram) presented to our hospital following radiographic detection of a suspicious grouped microcalcification in the upper outer quadrant of her right breast on the mammogram. A wide local excision of the right breast lump was performed. Following histopathological examination of the breast lump, the final diagnosis was breast adenomyoepithelioma with mucoepidermoid/divergent differentiation, with no evidence of malignancy. About two years after the operation, a ...
Case studies in surgery, 2015
Malignant myoepithelioma of the breast is a rare lesion characterized by the malignant proliferation of the epithelial and myoepithelial cells that exhibit characteristic histological and immuno-histochemical features. Very few cases have been reported in literature. We report a case of a 64-year-old female with a palpable lump in the upper outer quadrant of her right breast, present for a number of years. She underwent lumpectomy under local anesthesia. Upon histological confirmation of the diagnosis of malignant myoepithelioma, the patient underwent wide local excision with sentinel node mapping. Malignancy was evident by extensive central infarction. The tumour was completely triple negative, i.e. Estrogen receptor (ER), Progesterone receptor (PR) and Human epidermal growth factor receptor 2 (HER2) negative. The patient also underwent adjuvant chemotherapy and radiation therapy. The patient remains well with no recurrence 7 years since her initial surgery. The authors believe, that due to the paucity of these rare tumours, optimal treatment strategies remain to be determined.
Adenomyoepithelioma of the breast
Diagnostic Cytopathology, 2001
Adenomyoepithelioma is a rare breast tumor. Histologically it may disclose different patterns of growth, and some additional features may result in diagnostic errors. We describe 2 cases of adenomyoepithelioma of the breast initially examined by fine-needle aspiration biopsy (FNAB)
Adenomyoepithelioma of the Breast: An Intricate Diagnostic Problem
Breast Care, 2008
Hintergrund: Das Adenomyoepitheliom (AME) der Brust ist ein seltener, biphasischer Tumor mit epithelialen/myoepithelialen Anteilen. In einer Gewebeprobe ist ein AME leicht zu diagnostizieren, anhand einer Nadelbiopsie ist die sichere Diagnosestellung jedoch erschwert. Fallbericht: Wir berichten über den Fall einer 42-jährigen Patientin, die mit einem Knoten in der rechten Brust vorstellig wurde. Die Feinnadelbiopsie ergab ein C5-Karzinom. Der Patientin wurde eine neoadjuvante Therapie empfohlen, welche sie jedoch ablehnte. Daraufhin wurde sie an ein spezialisiertes Zentrum überwiesen, wo eine Nadelbiopsie durchgeführt wurde und die Diagnose eines möglichen AME gestellt wurde. Schlussfolgerung: Bei zytologischern Atypien in Nadelbiopsien kann es auf Grund der geringen Gewebemenge zur Verwechslung eines AME mit einem invasiven Duktalkarzinom kommen.
Adenomyoepithelial adenosis of breast: a rare case report
Turkish Journal of Pathology, 2013
Myoepithelial cells of the breast and their hyperplasia is found in many benign conditions resulting in a spectrum of lesions of myoepitheliosis to myoepithelial carcinoma. We present a rare case of adenomyoepithelial adenosis in a 17-year-old female who presented with a palpable right breast lump. although considered benign, adenomyoepithelial lesions have a high chance of recurrence due to inadequate excision. Recurrence and even metastasis are therefore important issues in the follow-up of adenomyoepithelial lesions.
Adenomyoepithelioma of the breast associated with low-grade adenosquamous and sarcomatoid carcinomas
Virchows Archiv, 1995
Six cases of invasive breast carcinoma with unusual morphological features are reported. The ages of the female patients ranged from 46 to 79 years (mean 60.5). All tumours had areas typical of an adenomyoepithelioma. In three cases adenomyoepithelioma gradually merged with low-grade adenosquamous carcinoma. In the other three patients a sarcomatoid carcinoma was associated with adenomyoepithelial areas, A common origin is proposed for these neoplasms, which extends the morphological spectrum of epi-myoepithelial cell tumours.
Diagnostic Cytopathology, 1998
Adenomyoepithelioma is a rare breast tumor. Histologically it may disclose different patterns of growth, and some additional features may result in diagnostic errors. We describe 2 cases of adenomyoepithelioma of the breast initially examined by fine-needle aspiration biopsy (FNAB). Cytologic features included hypercellularity, clusters of epithelial and myoepithelial cells with occasional intranuclear inclusions, prominent apocrine metaplasia, and foam cells. Histologically, both tumors were diagnosed as adenomyoepithelioma tubular-variant, with prominent myoepithelial clear cells, apocrine metaplasia, and foci of squamous metaplasia. Immunohistochemically, the tumors showed strong positivity for keratins CAM 5.2, AE1/AE3, and EMA in the epithelial component, while the myoepithelial cells reacted with muscle-specific actin (A14 and HHF35) and S-100 protein. We point out that FNAB in this rare tumor may exhibit a varied spectrum of cells that may result in confusion with other lesions, and we call attention to the presence of intranuclear inclusions. The latter observation in the present cases by cytologic and histologic assessment provides an additional feature to the morphological characteristics of adenomyoepithelioma of the breast.