Fas and Fas-Ligand Co-Expression by Small Intestine Epithelial Cells of Celiac Patients (original) (raw)

J Pediat Gastroenterol Nutr, 1998

Abstract

Aim. Analyse whether DNA fragmentation of enterocytes correlates with villus atrophy and investigate the mechanisms involved in the apoptotic process. Methods. Frozen duodenal biopsies from untreated CD with villus atrophy (UCD)(n= 12) or without villus atrophy [LGE, low-grade enteropathy (n= 8)(2), with only patches of villus atrophy], treated CD (TCD)(n= 12) and controls (n= 17) were analysed for DNA fragmentation [TUNEL method, number of positive cells/100 enterocytes,(3)], and by immunocytochemistry (4) for expression of FAS [ ...

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