Isolated lumbar-4 vertebral cryptococcosis in an immunocompetent patient—A case report and literature review (original) (raw)
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Isolated cryptococcal osteomyelitis in an immunocompetent patient
The Journal of Infection in Developing Countries, 2011
Cryptococcosis is a rare infection in HIV-negative individuals. While the lungs and the central nervous system are most commonly infected, skeletal cryptococcosis is uncommon and isolated osteomyelitis due to Cryptococcus neoformans is quite rare. To our knowledge, only 47 cases of isolated cryptococcal osteomyelitis have been reported from 1974 to 2005. We report a case of isolated cryptococcal osteomyelitis in an immunocompetent patient, who received 12 weeks of fluconazole with complete recovery.
Transverse Myelitis Associated with Cryptococcus neoformans in an Immunocompetent Patient
Case Reports in Infectious Diseases, 2021
Cryptococcus neoformans is a microscopic fungus that despite its pervasiveness in the environment rarely causes infection in immunocompetent patients. In immunosuppressed patients, infections involving the central nervous system (CNS) usually present as meningitis or meningoencephalitis. Cryptococcal infections are known to cause significant morbidity and mortality in immunosuppressed patients as it is difficult to eradicate even with adequate antifungal treatment. A 44-year-old Hispanic male presented to the hospital with headache, progressive urinary retention, neck and back pain, and right upper and bilateral lower extremity weakness for five days. Imaging revealed small foci in the white matter and revealed diffuse abnormal signal involving the cervical medullary junction extending up to the thoracic spine. Analysis of cerebral spinal fluid (CSF) obtained via lumbar puncture was positive for the Streptococcus antigen with cultures also growing Cryptococcus neoformans. Upon evaluation, patient was not found to be immunocompromised. is report works to highlight an atypical presentation of a cryptococcal CNS infection to raise awareness amongst clinicians hoping to prevent a delay in diagnosis of this disease given its high mortality.
Cryptococcal Osteomyelitis in an Immune-Competent Host: a Case Report
SN Comprehensive Clinical Medicine, 2019
We report a rare case of osteomyelitis due to Cryptococcus neoformans var. grubii in a non-immunosuppressed patient. The epidemiology, symptoms, diagnostics and treatment are discussed. The case illustrates the complexity of differential diagnosis of osteomyelitis.
A Case of Cryptococcal Osteomyelitis in a Solid Organ Transplant Patient
International journal of current research and review, 2021
Infections in transplant patients may be missed as they do not present with the usual clinical features. This leads to a delay in the diagnosis and thereby resulting in delayed treatment. Atypical organisms are also responsible for a variety of infections in these immunosuppressed individuals. The following case illustrates these points. Aim: To report an unusual manifestation of cryptococcal infection. Case Report: This is a case of a 63-year post-renal transplant lady. Three years after the transplant, she presented with a headache. CNS examination did not reveal any abnormality. Non-contrast CT showed well-defined hypodense collection measuring 2.8x 4.1x 3.5 in the right suboccipital region deep to the muscular plane with erosion and defect in the subjacent right occipital bone. Pus culture showed cryptococcus. She underwent drainage of abscess and surgery for osteomyelitis. She received 3 weeks of treatment with liposomal amphotericin B, followed by oral fluconazole. Discussion: Bone involvement occurs in only 5% of cases of cryptococcus. It most often affects the lumbar spine or lower extremities and rarely at other sites. Conclusion: It is important to be aware of this entity especially when managing immune-compromised individuals.
Garcia-Santibanez R, Gill V, Yancovitz S, Pyburn D. 58-year-old man presented with headache, nausea, vomiting, and gait disturbance. Brain MRI showed meningeal enhancement and herniation. Serum Cryptococcus antigen was positive but spinal fluid antigen and cultures were negative. A cerebellar biopsy revealed nonencapsulated Cryptococcus. He completed antifungal therapy. Serum Cryptococcus antigen titer decreased. He had a full neurological recovery. Case Rep Infect Dis. 2015. doi: 10.1155/2015/857539. PMID: 25954558
Disseminated Cryptococcus in Immunecompetent patient
Cryptococcosis is a fungal infection which is commonly associated with immune-compromised state. Disseminated infection in immunocompetent individuals is extremely rare. We present a case of a 56-year-old African American patient who presented with unilateral knee pain and swelling and was subsequently diagnosed with cryptococcal bone mass with dissemination of infection.
Acta Cytologica, 2000
but treatable disease that should remain in the differential diagnosis of lytic osseous lesions.