Relationship Between CARD15, SLC22A4/5, and DLG5 Polymorphisms and Early-Onset Inflammatory Bowel Diseases (original) (raw)

Profile image of Giuseppe Iacono Giuseppe Iacono

2006, Inflammatory Bowel Diseases

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7 pages

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Background: Inflammatory bowel disease (180) has been associated with several polymorph isms in genes likely involved in innate immune responses and integrity of epithelial mucosal barrier. A major role in adult Crohn's disease (CD) has been defined for 3 polymorph isms in the CARDI5 gene, whereas variants in the SLC22A4. SLC22A5. and DLG5 genes could have a minor contribution to IBD susceptibility.