The pathophysiology of psoriasis (original) (raw)
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Lepra vulgaris. History of Psoriasis
Journal of the turkish academy of dermatology, 2014
Background: The history of psoriasis, remains highly speculative for the time before Willan (1757-1812), and can be reliably assigned only for the last 200 years. Terms such as "Leprosy", "Impetigo" and "Psora" have been used in the centuries before. Hebra (1806-1880) gave a morphological and nosologic definition, in which also the histopathology appearance was taken into account. In the early 20th century, it was the biochemistry and histochemistry, which provided new insights. In the second half of the 20th century, immunocytochemistry and immunology shed some light on the pathogenetic processes of the disease. At the end of the 20th and at the beginning of the 21st century, it is the triumph of genetics and immunology, which have opened new therapeutic possibilities due to the interesting insights into the pathogenesis of psoriasis. However besides the new therapeutic modalities, which harbor some health and some economic threats, classical approaches still remain valuable tools.
Psoriasis: In a War with your Own Skin, Jacobs Journal of Experimental Dermatology
Psoriasis: At war with your own skin , 2019
125 million people worldwide -2% to 3% of the total population -have psoriasis, according to the World Psoriasis Day consortium. It is a genetic disease in which scaly, raised plaques appear on the skin. Psoriasis has been known since biblical times, and since then it is a mystery disease. Now we know many molecular and immune mechanisms for the development of psoriasis, but we still cannot fully understand what is considered the cause and what the effect is. In this article, we will give a general description of the disease, touch on its pathogenesis and tell the history of the study and treatment of psoriasis.
Psoriasis - A Systemic Disease
2012
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Journal of The American Academy of Dermatology, 2004
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