In: Antioxidants: New Research Oxidants and Antioxidants in Liver Disease (original) (raw)

Production of reactive oxygen and nitrogen species is an integral part of normal human metabolism and has been proved to have both beneficial and deleterious effects in various diseases including liver diseases. Normally neutralization of these oxidizing molecules occurs through their interaction with a complex system of antioxidant processes mediated by endogenous (superoxide dismutases, glutathione, albumin, billirubin etc.) and exogenous (polyphenols, vitamins etc.) molecules. In the last few decades numerous in vitro and in vivo studies have examined the effect of oxidants and antioxidants in the initiation and progression of alcohol-induced liver damage, toxic liver injury, liver ischemia/reperfusion injury, viral hepatitis, autoimmune hepatitis, cirrhosis, primary billiary cirrhosis, primary sclerosing cholangiitis and hepatocellular carcinoma. Non-parenchymal liver cells, like Kupffer cells and hepatic stellate cells, have also been reported to play an important role in the o...

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