518 Family history of gallstone disease determine the susceptibility to developing gallstone disease in mexicans patients (original) (raw)

BACKGROUND AND AIM. Leptin is a peptide secreted by adipocytes. This hormone is involved in the regulation of metabolism and is known to decrease food intake and increase energy expenditure. Serum leptin levels are higher in females than in males. It has been proposed that insulin increases leptin secretion. Cirrhotic patients frequently present a reduced body fat mass and increased leptin levels. The aim of this study was to evaluate leptin levels and to investigate the relationship between this hormone and the body mass index (BMI), body fat mass (FM) and fasting insulin levels in cirrhotic patients. MATERIAL AND METHODS. We studied 38 consecutive cirrhotic patients (l2F-26M; mean age 55.4± 14.5 yr.) Origin of liver disease was post-viral in 24, post-alcoholic in 8, cryptogenic in 3 and primary biliary cirrhosis in3 patients. FM was evaluated both by anthropometry (FM-A) and, only in 13 patients, by DEXA (FM-D). RESULTS. The results are shown in the table below. Fasting insulin levels in cirrhotics were higher than normal values. Leptin levels were higher than normal values particularly in females. Leptin correlates with FM-A (r=0.67-p<0.001) and with FM-D (r=0.84-p<0.001). Leptin also correlates with insulin levels (r=0.74-p<0.001), this correlation was higher in women (r=0.94-p<0.001). CONCLUSIONS. Our data show that leptin levels are higher in cirrhosis particularly in women. The reason of this alteration is still to be completely cleared. Leptin correlates with FM-A, FM-D and insulin levels. These correlations suggest an important role of this hormone in the alteration of metabolism in cirrhotic patients. FM·A('!o) FM·OEXA ('!o) Leptin(ng/ml) Insulln(flUlml) 6655 518 FAMILY HISTORY OF GALLSTONE DISEASE DETERMINE THE SUSCEPTIBILITY TO DEVELOPING GALLSTONE DIS-EASE IN MEXICANS PATIENTS.

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