Growth factors secreted by fibroblasts: role in healing diabetic foot ulcers (original) (raw)

The research investigates the role of fibroblast-secreted growth factors in the healing process of diabetic foot ulcers. It highlights how chronic wounds, particularly those associated with diabetes, derail the normal acute wound healing pathway due to factors such as inadequate blood supply and cellular senescence. By analyzing cytokine expression among fibroblasts, keratinocytes, and macrophages, the study elucidates the mechanisms whereby fibroblasts contribute to wound repair, suggesting that therapeutic strategies targeting these growth factors could enhance healing outcomes in diabetic patients.