Synthesis and Characterization of Layer-by-Layer Assembled pH-Sensitive Polymer/Glucose Oxidase Thin Films for Potential Controlled Insulin Release (original) (raw)

Abstract

Diabetes Mellitus is a chronic condition characterized by high glucose concentration in blood. This is caused by insufficient amount of functional insulin, which is needed by the body to convert glucose into usable energy. Functionalized drug delivery systems (DDS), which are self-regulated, could be a potential alternative to the conventional method of introducing insulin to the body. One advantage of insulin DDS is the controlled release of the drug, which avoids over-dosage and wastage. For the fabrication of the DDS, insulin was incorporated into a layer-by-layer film of pH-sensitive, [2-(dimethyl amino) ethyl aminoacrylate] (PDMAEMA) and glucose oxidase (GOD). Insulin was deposited between the PDMAEMA/GOD bilayers which served as the drug carrier. Exposure of the insulin-PDMAEMA-GOD films to high glucose concentrations results to the production of gluconic acid. Decreasing the pH would cause changes in conformation of the PDMAEMA, as a consequence, releasing the embedded insuli...

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