IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism (original) (raw)

IL-21, a key cytokine in T cell-dependent immune responses, plays a crucial role in germinal center (GC) B cell differentiation and proliferation. This study explores the intrinsic mechanisms by which IL-21 regulates these processes, emphasizing its importance in generating high-affinity antibodies. Results demonstrate that IL-21 signaling directly affects B cell behavior within GCs, influencing affinity maturation and memory B cell development, which are vital for long-lasting immunological memory.