Bronchial carcinoid tumors: A retrospective analysis of 126 patients (original) (raw)

1992, The Annals of Thoracic Surgery

cases of primary carcinoma of the lung were diagnosed at the Duke University Medical Center. During the same period, 126 patients (mean age, 53 f 13 years) were diagnosed with bronchial carcinoid. The overall survival was 78% for 5 years and 71% for 10 years. Surgical treatment in 106 patients included pneumonectomy (15), lobectomy (63 with 9 bronchoplastic procedures), stapled wedge resection (221, and bronchoscopic laser resection (6). The method of diagnosis was chest roentgenography (1211, chest computed tomography (77), mediastinal tomography (31), bronchoscopy (Sl), bronchoscopic brushing and washing (501, bronchoscopic biopsy (40), transthoracic needle biopsy (271, thoracotomy (loo), and autopsy (5). Univariate analysis of the medical history, presenting signs and symptoms, diagnostic test results, and pathologic data predicted improved survival (p < 0.001) for: female sex (n = 581, lthough bronchial carcinoid tumors were described A in the 1800s, it was Seigfreid Oberndorfer [l] who coined the term Karzinoide or "resembling carcinoma" in 1907. In 1930, Kramer grouped carcinoid tumors with cylindromas as bronchial adenomas because of their good prognosis compared with bronchogenic carcinoma. It later became apparent that there was a subset of carcinoid adenomas that were more aggressive and therefore were designated as "atypical" by Arrigoni and associates [3] in 1972. Over the last 30 years, several series of bronchial carcinoid tumors have appeared in the literature, but none of substantial size has described this clinical entity in detail with an emphasis on univariate and multivariate survival analysis in the modern era of immunocytochemistry, electron microscopy, and chemotherapy. asymptomatic presentation (n := 47), normal serum serotonin or urinary hydroxyindoleacetic acid levels (n = 76), peripheral location of the primary tumor (n = 50), pathologic stage I or I1 (n = 91), negative lymph nodes (n = 80), primary tumor 2 cm or less in diameter (n = 671, and typical histology (n = 80). No significance ( p > 0.1) was