Biofilm inhibition by a new Mn(II) complex with Sulfamethoxazole: Synthesis, spectroscopic characterization and crystal structure (original) (raw)
Related papers
International Journal of Molecular Sciences, 2021
The constantly growing resistance of bacteria to antibiotics and other antibacterial substances has led us to an era in which alternative antimicrobial therapies are urgently required. One promising approach is to target bacterial pathogens using metal complexes. Therefore, we investigated the possibility of utilizing series of manganese(II) complexes with heteroaromatic ligands: Alcohol, aldehyde, ketone, and carboxylic acid as inhibitors for biofilm formation of Pseudomonas aeruginosa. To complete the series mentioned above, Mn-dipyCO-NO3 with dipyridin-2-ylmethanone (dipyCO) was isolated, and then structurally (single-crystal X-ray analysis) and physicochemically characterized (FT-IR, TG, CV, magnetic susceptibility). The antibacterial activity of the compounds against representative Gram-negative and Gram-positive bacteria was also evaluated. It is worth highlighting that the results of the cytotoxicity assays performed (MTT, DHI HoloMonitorM4) indicate high cell viability of th...
Polyhedron, 2003
Reactions of 2,2-dimethylpentanedioic acid(2dmepdaH 2 ) and 3,3-dimethylpentanedioic acid (3dmepdaH 2 ) with Mn(CH 3 COO) 2 Á 4H 2 O yield the soluble complexes [Mn(2dmepda)] Á 1.5H 2 O (1) and [Mn(3dmepda)] Á H 2 O (2). Complex 1 reacts with ethanolic solutions of 2,2 0 -bipyridine or 1,10-phenanthroline to give [Mn 2 (2dmepda) 2 (bipy)] Á H 2 O (3) and [Mn(2dmepda)(phen)] (4), respectively. Similar reactions of 2 with these ligands generated [Mn 2 (3dmepda) 2 (bipy) 3 ] Á 5H 2 O (5) [Mn(3dmepda)(phen) 2 ] Á 7.25H 2 O (6). The molecular structure of 6 was determined by X-ray crystallography. The asymmetric unit contains two [Mn(3dmepda)(phen) 2 ] units with 14.5 waters of crystallisation. The two manganese complexes are of very similar structure. In each case the manganese atom is ligated by four nitrogen atoms from two chelating phen molecules and two oxygen atoms, one from each of the carboxylates moieties of the 3dmepda 2À ligand. Thus, the two carboxylate functions of the two 3dmepda 2À dianionic ligands are essentially monodentate. The 2,2-and the 3,3-dimethylpentanedioate complexes, the metal free ligands and a number of simple manganese salts were each tested for their ability to inhibit the growth of Candida albicans. Only the ''metal free'' 1,10-phenanthroline and its 2,2-and the 3,3-dimethylpentanedioate complexes exhibit fungitoxic activity.
Annals of Science and Technology
Three mixed ligand complexes of sulphamethoxazole and citric acid have been synthesized using Mn(II), Fe(III) and Ni(II) chlorides. The complexes were characterized by elemental analysis, melting point, conductivity test, magnetic measurement, UV-Visible and infrared spectroscopy. The infrared spectra data revealed that the ligands act as bidentate, in which citric acid coordinate through C=O of the carboxyl and oxygen of the hydroxyl groups, while sulphamethoxazole coordinates through nitrogen atom of the primary amine group and O=S=O of the sulphonyl group. The result of the elemental analysis was consistent with the proposed pattern for the complexes, while the melting point determination confirmed that the synthesized compounds were pure. Antibacterial activity of metal complexes were screening against five strain bacteria microorganism of g(+)Pseudomonas aeruginosa, Eschericia coli, g(+)Klebsiella pneumonia, g(+)Staphylococcus aureus and g(+)Candida using Muller Hinton diffusio...
Antimicrobial Activity of Mn Complexes Incorporating Schiff Bases: A Short Review
American Journal of Heterocyclic Chemistry, 2019
Antibiotic resistance has been growing at an anxious rate and as a result the activity of antibiotics against Gram-negative and Gram-positive bacteria has dropped dramatically day by day. Metal ions play many critical functions in humans. Deficiency of some metal ions can lead to disease like pernicious anemia, growth retardation, heart disease in infants etc. In this sense there is a strong need to synthesis new substances that not only have good spectrum of activity, but having new mechanisms of action. Inorganic compounds particularly Mn metal complexes have played an important role in the development of new metal based drugs. Over the past few years, there have been many reports on their applications in homogeneous and heterogeneous catalysis. The activity is usually increased by complexation therefore to understand the properties of both ligands and metal can lead to the synthesis of highly active compounds. The influence of certain metals on the biological activity of these compounds and their intrinsic chemical interest as multidentate ligands has prompted a considerable increase in the study of their coordination behavior. Development of a new chemotherapeutic Schiff bases and their metal complexes is now attracting the attention of medicinal chemists. In this review we have focused on research of Mn complexes incorporation of Schiff bases carry out over the past few decades which has sought to possess preclinical pharmacological screenings like anti-bacterial, anti-fungal, anti-tuberculosis, anti-inflammatory, anti-cancer, DNA-interaction and anti-tumor action of synthetic metal complexes.
Manganese (II) and Cobalt (II) Acetylacetonates as Antimicrobial Agents
Nigerian Annals of Pure and Applied Sciences , 2019
Mn(II) and Co(II) complexes were prepared by reaction of the metal chlorides with acetylacetone in ammonical aqueous medium. The metal complexes were prepared in order to investigate their antimicrobial activity on some selected pathogens. The characterisation of the complexes was on the basis of various spectroscopic techniques like infrared and ultraviolet studies. The compounds were subjected to antimicrobial activity screening using serial broth dilution method. Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal/Fungicidal Concentration (MBC/MFC) were determined. Mn(II) complex has shown significantly both antibacterial and antifungal activity with a MIC of 1.25 µg/mL while Co(II) complex was noticeable for antifungal activity at the same concentration. Whereas Mn(II) acetylacetonate is a more potent bactericide while Co(II) acetylacetonate is a more potent fungicide, both with MBC/MFC value of 2.5 µg/mL. Antimicrobial agent of the ligand has enhanced on complexation with Mn(II) and Co(II) ions. Though, the potency of the prepared antibiotics on the tested microbes is less compared to the standard drugs (Ciprofloxacin and Fulcin).
International Journal of Scientific Research in Science and Technology, 2023
The Present research work describes biological activity of amide group containing ligands and their Mn(II), Ni(II), Co(II) and Cu(II) complexes against E.coli and S.aureus. The standard disc diffusion method has been employed for investigations. The data obtained during study has been correlated for structure activity relationship and a trend has been pointed for a series of complexes.
Dutse Journal of Pure and Applied Sciences (DUJOPAS), 2020
Complexes of Mn(II)and Fe(II) with Schiff based derived fromsulfamethoxazole andfurfural have been prepared and characterized on the basis of physical characteristics, analytical data, FTIR spectral studies and elemental analysis. Infrared spectra of the Schiff base and the complexes agrees with the formation and chelation of the Schiff base through the azomethine nitrogen at 1629 cm-1 and aldehydic oxygen at 1288 cm-1. Molar conductance measurement of 5.29 and 9.68 Ohm-1 cm 2 mol-1 suggesteda nonelectrolytic nature of the complexes. Magnetic susceptibility data (5.84 and 5.12 BM)suggested octahedral structure for all the complexes. Elemental analysis suggested the ligand-metal ratio of2:1 respectively. The Schiff base melted at 180°C and the complexes decomposedat 232°C and 227°C implying thermal stability. The Schiff base and the complexes have been screened for their antimicrobial activity against four pathogenic microbes;Staphylococcus aureus, Escherichia coli, Aspergillus flavusand Candida albicans. The ligand showed moderate activity with inhibition zone in the range of 6-14mm, while the metal complexes exhibited higher antimicrobial activity with inhibition zone of 9-18mm against the tested microbes.
Indian Journal of Pharmacology, 2006
Objective: To investigate the bactericidal activity of manganese (IV) complex of 2-Molecular and Cellular methylamino-pyridine against Streptococcus pyogenes (S. pyogenes) and Staphylococcus Biology Department, aureus (S. aureus). Genetic Engineering and Materials and Methods: The inhibitory effect of the complex was studied on the molecular Biotechnology Research level and by turbidity measurement. Treatment of bacteria was carried out using 5, 10, 25, Institute, 50 and 100 µmol of the complex per ml of culture media. Minufiya University, Sadat City, Results: The results showed that the growth of S. pyogenes rapidly decreased with increas-Minufiya. Egypt ing concentrations of the complex. In contrast, the complex caused no significant decrease in the growth rate of S. aureus. The molecular level studies showed that four protein bands,
Five mononuclear complexes of manganese(II) of a group of the general formula, [MnL(NCS) 2 ] where the Schiff base L = N,N 0-bis[(pyridin-2-yl)ethylidene]ethane-1,2-diamine (L 1), (1); N,N 0-bis[(pyridin-2-yl)ben-zylidene]ethane-1,2-diamine (L 2), (2); N,N 0-bis[(pyridin-2-yl)methylidene]propane-1,2-diamine (L 3), (3); N,N 0-bis[(pyridin-2-yl)ethylidene]propane-1,2-diamine (L 4), (4) and N,N 0-bis[(pyridin-2-yl)benzyli-dene]propane-1,2-diamine (L 5), (5) have been prepared. The syntheses have been achieved by reacting manganese chloride with the corresponding tetradentate Schiff bases in presence of thiocyanate in the molar ratio of 1:1:2. The complexes have been characterized by IR spectroscopy, elemental analysis and other physicochemical studies, including crystal structure determination of 1, 2 and 4. Structural studies reveal that the complexes 1, 2 and 4 adopt highly distorted octahedral geometry. The antibacte-rial activity of all the complexes and their respective Schiff bases has been tested against Gram(+) and Gram(À) bacteria.
Metal-Based Drugs, 2002
Some manganese(II) complexes derived from different sulphadrugs and heterocyclic ketones have been prepared. These complexes have been characterized on the basis of elemental analyses, molecular weight determinations, conductivity measurements, infrared, ESR and magnetic measurements. The spectral data suggest that the ligands act in a monobasic, bidentate manner coordinating through nitrogen atom. A high spin tetrahedral geometry around this metal has been proposed on the basis of magnetic and spectral studies. The isolated products are coloured solids, soluble in DMSO, DMF and MeOH. All the complexes are monomeric in nature as indicated by their molecular weight determinations and conductivity measurements in dry DMF show them to be non-electrolytes. All the ligands and their corresponding complexes have been screened for their fungicidal, bactericidal and nematicidal activities.