Mass Balance Studies in Animals and Humans (original) (raw)

Encyclopedia of Drug Metabolism and Interactions, 2011

Abstract

ABSTRACT Mass balance studies play an important role in the development of new drugs. These studies give in-depth understanding of absorption, bioavailability, and routes (renal, biliary, hepatic, or gastrointestinal) and extent of excretion, metabolite profiling, metabolic pathways, and clearance mechanisms of a drug. In this chapter, fundamental scientific considerations for the successful design, conduct, and interpretation of conventional, basic mass balance and more comprehensive absorption, distribution, ...

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