Unusual Discordant Responses in Two Multiple Myeloma Patients during Bortezomib Treatment (original) (raw)

Onkologie, 2008

Abstract

Cases of discordant responses in multiple myeloma (MM) patients after thalidomide therapy have been sometimes reported, in which extramedullary masses progress or present de novo with a simultaneous serum monoclonal protein reduction. We hereby report, for the first time, on two cases of MM patients with extramedullary myeloma localizations that developed during Velcade (bortezomib, PS341) treatment with a concomitant serum monoclonal protein reduction. We observed in both patients a very good response in the serum monoclonal protein level, while extramedullary lesions appeared in the central nervous system and subcutaneously. We discuss pharmacokinetics of bortezomib and physiopathology of this unusual event and review the literature.

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