Immunogenicity of Salmonella pullorum killed vaccine in selected breeder flock (original) (raw)

Present study was carried out to study the immunogenicity of a commercial available formalin-killed alum-precipitated Salmonella pullorum vaccine manufactured by the Livestock and Poultry Vaccine Research and Production Centre (LPVRPC) at the Department of Microbiology and Hygiene, BAU, Mymensingh. accination was carried out on Shaver brown chicken (parent stock) of the Phenix Poultry Ltd. Located at Bhaluka, Mymensingh. Birds belonging to the group A (n=11,000) were used for vaccination, while birds of group B (n=10) was used as unvaccinated control group. Each bird was vaccinated intramuscularly at 65 days of age with a subsequent booster dose after 35 days of primary vaccination. Following primary vaccination the mean value of Passive Hemagglutinating (PHA) antibody titers of vaccinated birds, at 15, 30 and 35 days were 116.00±12.00, 96.00±8.26 and 88.00±11.71 respectively. While, the subsequences mean value of PHA antibody titers of vaccinated birds at 15 and 30 days following the booster vaccination were 128.00±10.12 and 108.00±7.66, respectively. The mean PHA antibody titer in chickens of unvaccinated control birds were ≤ 4.25±0.51. The findings demonstrated that the level of PHA titer after primary vaccination decreased immediately; however, after booster vaccination the level of titer of PHA antibody increased and sustained. Present study indicated that the S. pullorum killed vaccine prepared at by LPVRPC; significantly (p<0.01)) increased the level of PHA antibody in vaccinated chickens compared to unvaccinated control as determine by the PHA test..bd (MT Rahman) @2015 Int. J. Nat. Soc. Sci. all right reserved.