Cell Signalings and the Communications in Head and Neck Cancer (original) (raw)

Head and neck squamous cell carcinoma (HNSCC) is a prevalent neoplasm with a poor prognosis due to high rates of metastasis and limited treatment options. This paper discusses the critical role of the epidermal growth factor receptor (EGFR) in promoting cell survival and proliferation in HNSCC, detailing the signaling pathways involved and the emergence of resistance mutations. It emphasizes the potential of combining EGFR antagonists with chemopreventive agents like resveratrol, deguelin, and honokiol, which target interactions in cell signaling pathways to enhance clinical outcomes for HNSCC patients.