Regulation of hepatic cholesterol metabolism in humans: stimulatory effects of cholestyramine on HMG-CoA reductase activity and low density lipoprotein receptor expression in gallstone patients (original) (raw)

Biochemical and Biophysical Research Communications, 2007

Hepatic cholesterol metabolism in cholesterol gallstone disease

Journal of Lipid Research, 1991

Prevention of cholesterol gallstones by inhibiting hepatic biosynthesis and intestinal absorption of cholesterol

Ornella de Bari, Gabriella Garruti

European Journal of Clinical Investigation, 2013

Regulation of cholesterol 7 alpha-hydroxylase by hepatic 7 alpha-hydroxylated bile acid flux and newly synthesized cholesterol supply

Journal of Biological Chemistry

Effects of cholesterol uptake from high-density lipoprotein on bile secretion and 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in perfused rat liver

E. Bravo

Metabolism, 1993

Suppression of bile acid synthesis, but not of hepatic cholesterol 7α-hydroxylase expression, by obstructive cholestasis in humans

Francesca Carubbi, Silvia Ferrari

Hepatology, 2001

Regulation of Hepatic Low-Density Lipoprotein Receptor, 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase, and Cholesterol 7α-Hydroxylase mRNAs in Human Liver

The Journal of Clinical Endocrinology & Metabolism, 2002

Influence of newly synthesized cholesterol on bile acid synthesis during chronic inhibition of bile acid absorption

Marco BERTOLOTTI

Hepatology, 2003

Regulation and deregulation of cholesterol homeostasis: The liver as a metabolic "power station

Valentina Pallottini

World Journal of Hepatology, 2012

Monitoring hepatic cholesterol 7α-hydroxylase activity by assay of the stable bile acid intermediate 7α-hydroxy-4-cholesten-3-one in peripheral blood

Mats Rudling

Journal of Lipid Research, 2003

Cholesterol Synthesis Inhibition Elicits an Integrated Molecular Response in Human Livers Including Decreased ACAT2

Arteriosclerosis, Thrombosis, and Vascular Biology, 2008

Effects of simvastatin and cholestyramine on bile lipid composition and gallbladder motility in patients with hypercholesterolaemia

Piero Portincasa

Gastroenterology, 1995

Differing effects of cholesterol and taurocholate on steady state hepatic HMG-CoA reductase and cholesterol 7 alpha-hydroxylase activities and mRNA levels in the rat

Journal of lipid research, 1992

Comparative regulation of hepatic sterol 27-hydroxylase and cholesterol 7α-hydroxylase activities in the rat, guinea pig, and rabbit: Effects of cholesterol and bile acids

Lien Nguyen

Metabolism-clinical and Experimental, 1999

Differing effects of cholesterol and taurocholate on steady state hepatic HMG-CoA reductase and cholesterol 7~hydroxylase activities and mRNA levels in the rat

Lien Nguyen

Inhibitors of Cholesterol Biosynthesis Increase Hepatic Low-Density Lipoprotein Receptor Protein Degradation

Archives of Biochemistry and Biophysics, 1996

Determinants of transhepatic cholesterol flux and their relevance for gallstone formation

Silvana Zanlungo

Liver International, 2009

Bile acid synthesis in man: assay of hepatic microsomal cholesterol 7 alpha-hydroxylase activity by isotope dilution-mass spectrometry

Journal of lipid research, 1986

Influence of cholestyramine on synthesis of cholesterol and bile acids in germfree rats

2009

Regulation of Hepatic Low-Density Lipoprotein Receptor, 3Hydroxy3-Methylglutaryl Coenzyme A Reductase, and Cholesterol 7Hydroxylase mRNAs in Human Liver

2000

Cholecystectomy prevents expansion of the bile acid pool and inhibition of cholesterol 7alpha-hydroxylase in rabbits fed cholesterol

Frederick Suchy

Journal of lipid research, 2001

Correlation between plasma levels of 7α-hydroxy-4-cholesten-3-one and cholesterol 7α-hydroxylation rates in vivo in hyperlipidemic patients

Marco BERTOLOTTI

Steroids, 2008

Increasing hepatic cholesterol 7alpha-hydroxylase reduces plasma cholesterol concentrations in normocholesterolemic and hypercholesterolemic rabbits

Hepatology, 1996

Increasing dietary cholesterol induces different regulation of classic and alternative bile acid synthesis

Lien Nguyen

Journal of Clinical Investigation, 1999

The mechanisms of and the interrelationship between bile acid and chylomicron-mediated regulation of hepatic cholesterol synthesis in the liver of the rat

Flavio Nervi

Journal of Clinical Investigation, 1978

Cholecystectomy increases hepatic triglyceride content and very-low-density lipoproteins production in mice

Flavio Nervi

Liver International, 2011

Overexpression of cholesterol 7α-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis

Lisa-mari Nilsson

Hepatology, 2011