T-lymphocyte subpopulations in patients with various courses after hepatitis B virus infection (original) (raw)

Scandinavian journal of gastroenterology, 1984

Abstract

The course of a hepatitis B virus infection is probably determined by the cellular immune response of the host, which is partly regulated by the T helper and T suppressor cells. We therefore counted immunoregulatory T-cell subsets in the peripheral blood of 97 patients with various courses of hepatitis B virus infection: 23 of these patients were asymptomatic HBsAg carriers without detectable liver disease, 13 had chronic persistent hepatitis B, 19 had chronic active hepatitis B (11 HBeAg, 8 anti-HBe), 7 had chronic active hepatitis with anti-HBs or anti-HBc, and 35 were healthy controls with anti-HBs after recovery from acute hepatitis B. Peripheral blood mononuclear cells were specifically labelled with monoclonal Leu-1 (T cells), Leu-2a (T suppressor/cytotoxic cells), and Leu-3a (T helper cells) antisera and analyzed by flow cytometry. Leu-3a/Leu-2a ratios for patients with persistent virus infection did not differ from those found for patients who cleared the hepatitis virus ant...

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