The WASP–Arp2/3 pathway: genetic insights (original) (raw)

This review discusses recent genetic and loss-of-function studies that have advanced the understanding of how the WASP protein family and the Arp2/3 complex regulate actin assembly, crucial for cellular processes like motility and embryogenesis. Key findings include the conservation of Arp2/3's nucleating role across eukaryotes and the specific contributions of WASP/Scar family proteins in nucleation, signaling pathways, and their unique roles in various cell types. The review also suggests future research directions to further elucidate the dynamics of actin filament generation and regulation.