Selective polymorph transformation via solvent-drop grinding (original) (raw)

Selective polymorph transformation is achieved through a novel method called solvent-drop grinding, showcasing importance for various disciplines such as pharmaceuticals. By mixing solid-state grinding techniques with controlled amounts of solvent, the method enhances the kinetics of cocrystallization and selectively directs crystallization outcomes. Results with anthranilic acid and succinic acid demonstrate that this approach can improve polymorphic selectivity beyond traditional crystallization methods.