Histopathological study of neoplastic lesions of large intestine in Kashmir Valley, India (original) (raw)
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Histopathological Evaluation of Colorectal Carcinomas Status in Manipur, India
… Journal of Pathology, 2010
Materials were collected from subjects first diagnosed as colorectal carcinomas in histopathology section and then the medical files were reviewed. Variables like age, sex, religion, relevant past / family history, tumor location, disease stage (Dukes' staging) were assessed. The findings were then analysed. Results: There were 54 patients with colorectal carcinomas during this 6 year period. 29 cases (53.71%) were males while 25 cases (46.29%) were females with a male to female ratio of 1.16:1. The disease was most commonly seen between 60-69 years age group. The rectum was the most common affected site contributing to 53.71% (29 cases) followed by ascending colon with 12 cases (22.22%). 38.88% of lesions (21 cases) were stage C and above i.e. involvement of local lymph nodes and distant metastasis. When we compared patients above 50 years of age to those under 50 years of age, we found that the disease usually presented with poorer grades of differentiation and more advanced stage in those below 50 years compared to those above 50 years. Conclusions: This study showed that bowel cancers are not rare as previously believed. Routine screening for bowel cancer in all risk patients should be carried out regularly so as to detect cancer early.
2016
Background: Carcinoma of the colon and rectum is a relatively uncommon malignancy in India when compared with the western world. Colorectal cancer is generally a disease affecting individuals 50 years of age and older and is much less common in persons under 40 years of age. Aims: To study relative frequency of colonic carcinoma with regard to demographic data, histological types and pathologic stages. Materials and methods: We studied total of 409 colorectal carcinomas (CRC), diagnosed during the past 15 years i.e., from January 2001 to December 2015. The records were analysed in detail for age, gender, site of primary tumour, histopathological type, and pathological stage. Results: Four hundred and nine patients were diagnosed to have CRC. Majority were males (54.77%), rectum was commonest site (57.7%). Most of them were adenocarcinoma (54.52%) followed by mucin‑secreting adenocarcinomas (22.49%) and squamous cell carcinoma in 9.29%. Most of them presented at IIB stage (40.09%). Patients less than 40 years (30.81%) showed less favourable histology and higher grade of tumor. Conclusions: In CRC, rectal cancers are the most common cancers. Incidence of CRC in young is increasing. Screening for colorectal cancers and early evaluation of symptomatic cases need to be defined in developing countries.
Colorectal Cancer in India: An Iceberg Analysis from North India
Journal of Evolution of Medical and Dental Sciences, 2016
Colon and rectal cancers share many environmental risk factors and are both found in individuals with specific genetic syndromes. Carcinomas are rare before the age of 40 years except in individuals with genetic predisposition or predisposing conditions such as chronic inflammatory bowel disease. The incidence is increasing in Indian scenario, therefore there is need to study the disease behaviour, presentations and prognostic factors. AIMS To analyse various histological parameters of colorectal carcinoma and to correlate these parameters with each other and with Ki-67 wherever available. MATERIAL AND METHODS A total of 200 colectomy done for colorectal carcinoma and received in the Department of Pathology, Dayanand Medical College and Hospital during 4-year period were analysed with reference to Histological subtype, grade, stage and correlated these parameters and with Ki-67 wherever available. RESULTS Mean age of presentation of patients with colon carcinoma was 54.2±14.2years with male female ratio being 1.8:1. Rectosigmoid colon was the commonest site of tumor followed by caecum. Adenocarcinoma NOS with moderate differentiation was the commonest histological subtype. Most common T, N and M stage of presentation was T3, N0 and M0 respectively. Features associated with higher stage were young age, male sex, left sided tumors, signet ring cell & mucinous subtypes, higher grade, infiltrative tumor margins, no lymphocytic response at the advancing edges. MIB 1 labelling index was higher in Stage II patients. CONCLUSION Colorectal carcinomas are less common in Indian population however the incidence is increasing. Therefore the pathologist and clinicians must be aware of precursor lesions and prognostic factors to diagnose and treat the colorectal carcinomas at early stage.
Clinical Epidemiology and Global Health
Background: The frequency of colorectal carcinoma is inadequate in India compared to the western world. The carcinoma of colon and rectum is usually disturbing among the individuals of older age group whereas it is less frequent in younger age group. This study was based on age, gender, site of primary tumor and histopathological type of colorectal cancer cases. Methods: A retrospective study of 420 colorectal carcinoma cases admitted to Chittaranjan National Cancer Institute hospital, Kolkata, India during 2012-2016 was carried out. All the clinicopathological data was collected from the medical records of the patients. The detailed information was entered into tabular sheet and statistical analysis was performed. Results: During these five years out of total cases in the Department of Surgical Oncology, 5.09% patients with colorectal carcinoma were admitted for colectomy or hemicolectomy. The percentage of younger age group (40 year) with colorectal cancer was rise up sharply in context of older age group (>60 year). The ratio of male and female affected in colorectal cancer was 1.6:1. Rectum was the most common site 46.2% among the total cancer lesions. From histopathological data, mucinous adenocarcinoma cases were identified with (23.6%) high frequency and mostly detected at younger age group (65.7%). It was found that 18.8% patients with synchronous liver metastasis and 16.7% of patients with Type 2 diabetes mellitus were likely to develop colorectal cancer. Conclusion: The concise overview has documented an increased incidence of colorectal carcinoma patients amongst younger individuals with more aggressive forms like mucinous adenocarcinoma and also development of synchronous liver metastasis.
Retrospective Study of Distribution of Colorectal Cancers in North Coastal Andhra Pradesh
Journal of Evidence Based Medicine and Healthcare, 2019
BACKGROUND Colorectal cancers are the third most common cancers in India. Indian data on epidemiological factors and site of distribution of colorectal cancers is very limited. Colorectal cancer is the fourth most common newly diagnosed cancer after ca prostate, ca breast, and ca lung. Age standardized incidence rate of colorectal cancer in developed countries is between 25 to 30 per 100,000 population. In India it is 3 to 4 per 100,000 population. High ratios of colon to rectal cancer (≥2: 1) prevail in high-risk areas such as North America. Ratios below 1 are often found in low-risk Asian and African populations. Temporal trends in western studies showed increase in proximal colon malignancies and decrease in distal colon and rectal malignancies. Western studies showed increase in rectal cancer in individuals less than 50 yrs. probably attributable to dietary changes. Screening Guidelines-Faecal occult blood test every 3 yrs, Sigmoidoscopy every 5 yrs., Colonoscopy every 10 yrs. MATERIALS AND METHODS This is a retrospective study of all diagnostic colonoscopies of patients aged 18 and above who presented to Department of Gastroenterology, KGH between 2007 and 2014. Data is drawn to age, sex and site of cancer and analysed. RESULTS 1045 oncoscopies were done. 129 cases were diagnosed as colorectal malignancies and confirmed by biopsy. 52 cases were seen in rectum. 42 cases were seen in ascending colon. 10 malignancies in transverse colon, 12 in descending colon, 13 in sigmoid colon, 65 cases approximating 50% were seen in rectum and sigmoid colon. CONCLUSION Colorectal malignancies are not as frequent in India as in western world. Observational studies show increasing incidence of colorectal malignancies probably related to increased fatty diet and decreased fibre diet. Carcinoma rectum is more common than ascending colon cancers in India which is also found in studies done in other geographical regions. This could be attributed to genetics, environmental factors and dietary habits. Routine colonoscopy as a screening method for colorectal cancers need not be enforced in our geographical area. This observation needs to be confirmed by further studies.
Evaluation of Demographic and Clinical Presentation of Colorectal Carcinoma in Rajshahi Region
2020
This cross-sectional, descriptive, observational study was carried out for a period of 24 months from January 2014 to December 2015 in the Department of Pathology and Department of Surgery, Rajshahi Medical College, Rajshahi for evaluation of clinical and histological presentation of colorectal carcinoma patients in total fifty four patient. Data were collected by face to face interview, clinical examination. The study revealed that the colorectal carcinoma was highest in the 5 and 6 decade and rectal area (46.3%) and male predominance was observed with male to female ratio being 3:2. Abdominal pain (61.1%), weight loss (61.1%), per rectal bleeding (57.4%), altered bowel habit (24.1%) and melena (24.1%) are the main presenting symptoms. In terms of ABO blood grouping, blood group ‘B’ was found predominant (44.4%), followed by group ‘A’ (24.1%), group ‘AB’ (14.8%) and group ‘O’ (16.7%).
Clinico-pathological characteristics of colorectal carcinoma at university teaching hospital, Nepal
Journal of Patan Academy of Health Sciences, 2015
Introductions: Colorectal cancer is a major health problem in developing countries. The purpose of this study was to analyze the clinico-pathological characteristics of colorectal carcinoma at Patan hospital, Nepal. Methods: A retrospective chart review was done for patients operated for colorectal carcinoma at Patan Hospital from May 2004 to April 2012. Demographic information, chief complains, site of primary cancer, and histological types were analyzed. Results: There were 73 patients (37 males and 36 females) with colorectal carcinoma. The mean age was 52 years. There were 21 (28.77%) patients below 40 years of age. Patients with rectal carcinoma presented with bleeding per rectum in 69.70% and 60% of patients with colon cancer presented with pain abdomen. Rectum was involved in 31 (42.47%) and right colon in 30 (41.10%). Adenocarcinoma was seen in 72 (98.63%). Conclusions: The colorectal carcinoma is not only the disease of old age. We had 29% of our patients below 40 year. Rectum and right colon were equally affected.
Asian journal of pharmaceutical and clinical research, 2022
Objective: According to GLOBOCAN 2020, colorectal cancer is the fourth most lethal cancer in infected patients worldwide, with 1.7 million new cases recorded each year. When we look at Indian population studies, their mortality, incidence, and prevalence rates are consistently increasing compared to other European countries. Only a few studies have been reported on the clinical profile of CRC in India. Compared to females, males are more affected. This study was carried out to study the age, sex, and size distribution of malignant colon cancer and correlate the histopathological spectrum of colonic biopsies with clinical findings. Methods: Our study was a unicenter-based prospective study carried out over 2 years. All colonoscopic biopsies have been received in the Department of pathology, Aarupadai Medical College, and Hospital. Colonoscopies biopsies and colonic resection specimens are routinely fixed with 10% formalin and processed through an automatic tissue processor. Further, slides were stained with hematoxylin and eosin stains and examined for microscopic examination. Data generated from microscope observation were used for statistical analysis. Results: Our study included 54 patients with colorectal cancer. Among the patients, males were outnumbered by female patients, having an M: F ratio of 1:7:1. The most common age group affected is between the ages of 61 and 70. Adenocarcinoma was the most common histological malignancy (83%), followed by mucinous adenocarcinoma (7%), neuroendocrine carcinoma (4%), signet ring cell carcinoma (4%), and malignant melanoma (2%). Conclusion: Histopathological evaluation is the gold standard for the early detection of the gastrointestinal tract diseases, especially malignant diseases, which helps in the early prevention measures. Further, detailed studies on immunohistochemistry and molecular studies on colonoscopy biopsy specimens should be done in constant correlation with clinical features to help early detection of CRC and therapeutic prognostic purposes.
Kathmandu University Medical Journal, 2015
Background Colonoscopy is the method to visualize the mucosa of the entire colon and terminal ileum to detect the intestinal abnormalities and obtain biopsy for definitive diagnosis. For clinical decisions in the diagnosis of various colonic lesions unambiguous interpretation of colorectal biopsies is necessary. Objectives To assess the prevalence pattern of colonic diseases and to correlate the incidence of colorectal carcinoma with age, sex, site and symptoms presented at Dhulikhel Hospital. Methods The materials consisted of 126 biopsies which were submitted to the Department of Pathology, Kathmandu University School of Medical Sciences, Dhulikhel, during the period of July 2011- July 2012 .Data collected and entered in MS-Excel and were analyzed using SPSS-16. Results Out of 126 colonoscopic biopsies 34(27%) showed chronic nonspecific inflammation, followed by carcinoma 25(19.8%), non-neoplastic polyps 21(16.7%), granulomatous inflammation 14(11.1%), neoplastic polyps 8(6.3%), u...
A Study on the Clinicopathological Profile of the Cases of Colorectal Carcinoma
Journal of Pharmaceutical Research International, 2021
Aim: To assess the clinicopathological details of patients with colorectal cancer in a tertiary care centre in India and compare it other studies reported in the literature. Study Design: This is a retrospective study conducted on all the patients who were admitted in the period of 2017 to 2020. Place and Duration of Study: Department of Pathology, Saveetha Medical College, Thandalam, Chennai. The data was processed and the manuscript was prepared between June 2020 and January 2021. Methodology: Patient details were collected from the histopathology records and the parameters studied were age, gender, tumour site, histological type, differentiation and tumour stage of the colorectal carcinoma. The sampling was done using the complete enumerate sampling method. The patients diagnosed histopathologically as colorectal carcinoma were included in our study. Results: A total of 51 patients had been admitted in the years 2017, 2018, and 2019 in our institute. There was a female predominan...