Synthesis and Biological Activities of (R)-5, 6-Dihydro-N, N-Dimethyl-4H-Imidazo [4, 5, 1-Ij] Quinolin-5-Amine and Its Metabolites (original) (raw)

J. Med. …, 1997

Abstract

The imidazoquinoline (R)-5,6-dihydro-N,N-dimethyl-4H-imidazo[4,5,1-ij]quinolin-5-amine [(R)-3] is a potent dopamine agonist when tested in animals but surprisingly shows very low affinity in in vitro binding assays. When incubated with mouse or monkey liver S9 microsomes, ...

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