Functional Plasticity of Dendritic Cell Subsets as Mediated by CD40 Versus B7 Activation (original) (raw)

Dendritic cells (DCs) are key antigen-presenting cells that play significant roles in both immunity and tolerance. The ability of DCs to shape T cell responses depend on their subsets, activation state, and environmental cues. This research explores how CD40 and B7 activation mediates the functional plasticity of different DC subsets, shedding light on their ability to present antigens in immunogenic or tolerogenic manners. It is proposed that DCs possess instructive capabilities influenced by various signals, contributing to the understanding of their complex role in immune regulation.