Role of nutritional status in predicting quality of life outcomes in cancer – a systematic review of the epidemiological literature (original) (raw)
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Relationship between nutritional status and quality of life in patients with cancer
European Journal of Cancer, 2008
Patients with cancer frequently suffer a deteriorated quality of life and this is an important factor in the therapeutic decision. The correlation between quality of life and malnutrition seems obvious and bidirectional. The aim of our study was to describe the global quality of life and its various dimensions in patients with cancer, as a function of the nutritional status.
The annals of clinical and analytical medicine, 2022
Aim: Cancers affecting the gastrointestinal tract are common worldwide, and cancers of the stomach and pancreas have a poor prognosis. Supporting nutritional status before, during and after cancer treatment improves the effectiveness of treatment and quality of life. Malnutrition is seen in cancer patients due to loss of appetite, nausea, vomiting, diarrhea, chewing or swallowing problems, taste and smell changes, therefore malnutrition should be evaluated in all cancer patients and appropriate nutritional support should be initiated. In this study, we aimed to evaluate the effect of nutritional status on malnutrition and quality of life in patients with gastrointestinal system cancer. Material and Methods: The cross-sectional study included 60 patients who received gastrointestinal system treatment and met the inclusion criteria. The Quality of Life Test (EORTC QLQ-C30) and NRS-2002 were administered to the patients by the investigator using a face-to-face method. Socio-demographic information, anthropometric measurements and biochemical findings were obtained from patient files with hospital permission. Results: In the study, most of the patients were at risk of malnutrition; however, no significant correlation was found between NRS 2002 and quality of life and cancer stages. There was an inverse relationship between albumin levels and malnutrition risk (p<0.05). Discussion: Cancer patients are at risk of malnutrition due to the heavy treatment brought by the disease, therefore, malnutrition risks should be determined in the early period, appropriate nutritional support should be provided and their quality of life should be improved.
Nutrition and Cancer, 2020
Rationale and aims: Malnutrition is common and multifactorial in cancer patients (CP), combining the systemic inflammatory process with decreased food intake, loss of muscle and bone mass, and decreased functional status (FS). We aimed to track and evaluate the nutritional status (NS) of CP; associate results between hospitalized patients (HP) and day hospital patients (DHP); associate NS with tumor, symptoms, and FS. Methods: Cross-sectional observational study in HP or DHP from Garcia de Orta Hospital, over 18 years old. NS was monitored and evaluated using Nutritional Risk Screening (NRS-2002), Patient-Generated Subjective Global Assessment (PG-SGA), and anthropometric and biochemical parameters. To assess FS we used the Eastern Cooperative Oncology Group (ECOG), Karnofsky Performance Scale Index (KPSI), and handgrip dynamometer (HGD). Results: The 265 CP (114-HP, 151-DHP), of which 34.2%-HP and 17.2%-DHP had low BMI. From NRS-2002, 86.0% and 35.8% were respectively at nutritional risk. Using PG-SGA, 93.0% and 39.7% were respectively malnourished. PG-SGA were positively correlated with ECOG (p < 0.01) and negatively correlated with KPSI (p < 0.01), BMI (p < 0.01), and handgrip strength-HGS (p < 0.01-DHP and p < 0.05-HP). Conclusions: PG-SGA and FS scales are appropriate and validated tools for early identification of malnutrition and FS in CP. HGD can be a useful tool for assessing FS and NS.
Can nutritional status influence the quality of life of cancer patients?
Revista de …, 2010
Rev. Nutr., Campinas, 23 :745-753, set./out., 2010 Revista de Nutrição ORIGINAL | ORIGINAL 1 Artigo elaborado a partir da dissertação de L.R. BORGES, intitulada "Fatores determinantes da qualidade de vida em uma coorte de pacientes submetidos à quimioterapia". Universidade Católica de Pelotas; 2008.
Heliyon, 2020
Background: Quality of Life (QoL), for long, has been a multifactorial concerning issue in oncology. The aim of this study was to determine QoL of cancer patients and its association with nutrition, and performance status. Methodology: This was a hospital based cross-sectional study carried out at 2 cancer centers and one tertiary level hospital in Dhaka city during the months of July to December, 2019. Data was collected through structured interviews and analyzed by SPSS-25 statistical package software. Results: Among 279 participants, 14(5.02%) had high QoL, 35(12.54%) had average QoL, 150(53.76%) had low QoL, and remaining 80(28.67%) had very low QoL. The prevalence of severe malnutrition was 12.5% and 43.7% of patients had poor performance status. A statistically significant association between QoL and, nutritional and performance status was identified (p < 0.05). The ANOVA also indicated a statistically significant variation in QoL score among nutritional categories (P < 0.01) and performance status (P ¼ 0.013). Conclusion: A relatively higher prevalence of poor QoL was identified in this study which varies among nutritional categories and performance statuses. The proper management of predictors of QoL is imperative during treatment procedures.
Nutrição e Saúde Pública: pesquisas emergentes em produção e consumo de alimentos, 2021
Objective: To assess, through different tools, the influence of nutritional status and sarcopenia on the quality of life and survival in patients with gastrointestinal cancer on palliative chemotherapy. Methods: A prospective longitudinal study was done in patients with gastrointestinal cancer on palliative chemotherapy. Patient-generated subjective global assessment (PG-SGA) and the EORTC-QLQ-C30 were carried out in 3 evaluations (T1-3). Sarcopenia with EWGSOP2 criteria, including handgrip strength, bioimpedance and computed tomography and gait speed test. Results: 57 patients were included. The mean age was 62 ± 11.7 yr, 56% male and 35% with colorectal cancer. Moderate / severe malnutrition reached 86% of the group. The quality of life (QoLwas worse in patients with severe malnutrition (PG-SGA C) (p <0.001). The severity of sarcopenia was inversely proportional to the QoL (p = 0.05). Concerning survival, patients with severe sarcopenia, have a survival rate of 6.5 months (95% CI). Likewise, severely malnourished patients survived for 9.1 months (95% CI). Conclusion: The severity of malnutrition and sarcopenia reduced the survival and the quality of life of patients with gastrointestinal cancer on palliative chemotherapy.
Nutritional Factors during and after Cancer: Impacts on Survival and Quality of Life
Nutrients
The French National Cancer Institute conducted a collective expertise study with researchers and clinical experts from the French Network for Nutrition And Cancer Research (NACRe Network). The objective was to update the state of knowledge on the impacts of nutritional factors on clinical endpoints during or after cancer. Data from 150 meta-analyses, pooled analyses or intervention trials and 93 cohort studies were examined; they concerned 8 nutritional factors, 6 clinical events and 20 cancer locations. This report shows that some nutritional factors have impacts on mortality and on the risks of recurrence or second primary cancer in cancer patients. Therefore, high-risk nutritional conditions can be encountered for certain cancer sites: from the diagnosis and throughout the health care pathways, weight loss (lung and esophageal cancers), malnutrition (lung, esophageal, colorectal, pancreatic, gastric and liver cancers), weight gain (colorectal, breast and kidney cancers) and alcoh...
Identifying Malnutrition: Nutritional Status in Newly Diagnosed Patients With Cancer
Clinical journal of oncology nursing, 2017
Malnutrition is common among patients with cancer, but little attention is given to its risks and consequences. The aim of this study is to assess the nutritional status and identify the factors associated with malnutrition among newly diagnosed patients with cancer. Patients admitted with newly diagnosed cancer at a teaching hospital in Malaysia were recruited from January to April 2015. Nutritional status was assessed before treatment initiation, and patients were classified into three categories. A total of 132 pretreatment patients were recruited into the study. About half were severely malnourished. Patients with stage III cancer had the highest prevalence of severe malnourishment. Clinical parameters and disease characteristics were significantly associated with nutritional status. Demographic variables were also statistically significantly associated with severe nutritional status.
Nutritional intervention and quality of life in adult oncology patients
Clinical Nutrition, 2007
The evaluation of quality of life (QoL) assesses patients' well-being by taking into account physical, psychological and social conditions. Cancer and its treatment result in severe biochemical and physiological alterations associated with a deterioration of QoL. These metabolic changes lead to decreased food intake and promote wasting. Cancer-related malnutrition can evolve to cancer cachexia due to complex interactions between proinflammatory cytokines and host metabolism. Beside and beyond the physical and the metabolic effects of cancer, patients often suffer as well from psychological distress, including depression. Depending on the type of cancer treatment (either curative or palliative) and on patients' clinical conditions and nutritional status, adequate and patient-tailored nutritional intervention should be prescribed (diet counselling, oral supplementation, enteral or total parenteral nutrition). Such an approach, which should be started as early as possible, can reduce or even reverse their poor nutritional status, improve their performance status and consequently their QoL. Nutritional intervention accompanying curative treatment has an additional and specific role, which is to increase the tolerance and response to the oncology treatment, decrease the rate of complications and possibly reduce morbidity by optimizing the balance between energy expenditure and food intake. In palliative care, nutritional support aims at improving patient's QoL by controlling symptoms such as nausea, vomiting and pain related to food intake and postponing loss of autonomy. The literature review supports that nutritional care should be integrated into the global oncology care because of its significant contribution to QoL. Furthermore, the assessment of QoL should be part of the evaluation of any nutritional support to optimize its adequacy to the patient's needs and expectations.