original ) (raw )Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice
Steven Leach
Proceedings of the National Academy of Sciences, 2008
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Ngn3+ endocrine progenitor cells control the fate and morphogenesis of pancreatic ductal epithelium
Beatriz Sosa-pineda , Ruth Ashery-Padan
Developmental Biology, 2011
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Hes1 Controls Exocrine Cell Plasticity and Restricts Development of Pancreatic Ductal Adenocarcinoma in a Mouse Model
Marcel Lee
The American Journal of Pathology, 2016
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Preinvasive pancreatic neoplasia of ductal phenotype induced by acinar cell targeting of mutant Kras in transgenic mice
Paul Grippo
Cancer research, 2003
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Pdx-1 Activates Islet - and -Cell Proliferation via a Mechanism Regulated by Transient Receptor Potential Cation Channels 3 and 6 and Extracellular Signal-Regulated Kinases 1 and 2
Jonathan Schisler
Molecular and Cellular Biology, 2013
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Pancreatic DCLK1(+) cells originate distinctly from PDX1(+) progenitors and contribute to the initiation of intraductal papillary mucinous neoplasm in mice
wanglong Qiu
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Data from Dynamic Regulation of Expression of KRAS and Its Effectors Determines the Ability to Initiate Tumorigenesis in Pancreatic Acinar Cells
Luc Bouwens
2023
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Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice
Jean-Christophe BRISSET
Journal of Clinical Investigation, 2012
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Pdx-1 activates islet α- and β-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2
Jon Haldeman
Molecular and cellular biology, 2013
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Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor α
Steven Leach
Gastroenterology, 1999
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Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
Ben Hitt
Cancer Cell, 2004
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PDX:PBX complexes are required for normal proliferation of pancreatic cells during development
B. Peers
Proceedings of the National Academy of Sciences, 2001
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Mist1-KrasG12D Knock-In Mice Develop Mixed Differentiation Metastatic Exocrine Pancreatic Carcinoma and Hepatocellular Carcinoma
Nicholas Willis
Cancer Research, 2006
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KrasG12D induces EGFR-MYC cross signaling in murine primary pancreatic ductal epithelial cells
Matthias Wirth
Oncogene, 2015
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Pancreatic duodenal homeobox-1 and islet neogenesis-associated protein: a possible combined marker of activateable pancreatic cell precursors
Luis Flores
Journal of Endocrinology, 2003
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PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance
MOHAMEDI BRAHIM
Genes & development, 2016
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What We Have Learned About Pancreatic Cancer From Mouse Models
Carmen Guerra
Gastroenterology, 2012
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Duct- to islet-cell differentiation and islet growth in the pancreas of duct-ligated adult rats
Luc Bouwens
Diabetologia, 1995
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One process for pancreatic -cell coalescence into islets involves an epithelial-mesenchymal transition
Miranda Anderson
Journal of Endocrinology, 2009
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The Developmental Regulator Pax6 Is Essential for Maintenance of Islet Cell Function in the Adult Mouse Pancreas
Veronica van Heyningen
PLoS ONE, 2013
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PDX-1 Function is Specifically Required in Embryonic Β cells to Generate Appropriate Numbers of Endocrine Cell Types and Maintain Glucose Homeostasis
Mark A Magnuson
Developmental Biology, 2008
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Foxa2 Controls Pdx1 Gene Expression In Pancreatic β-Cells In Vivo
Klaus Kaestner
Diabetes, 2002
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The expression of the receptor for advanced glycation endproducts (RAGE) is permissive for early pancreatic neoplasia
Michael Lotze
Proceedings of the National Academy of Sciences of the United States of America, 2012
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Pancreatic Tumorigenesis: Oncogenic KRAS and the Vulnerability of the Pancreas to Obesity
Jianjia Ma
2021
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Identification of known and novel pancreas genes expressed downstream of Nkx2.2 during development
peter white
BMC Developmental Biology, 2009
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Glucose Is Necessary for Embryonic Pancreatic Endocrine Cell Differentiation
Gabriela Xavier
Journal of Biological Chemistry, 2007
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Signals for death and differentiation: a two-step mechanism for in vitro transformation of adult islets of Langerhans to duct epithelial structures
D. Maysinger
Cell Death and Differentiation, 2003
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Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues
Pawel K. Mazur
2012
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Cellular mechanisms involved in the recapitulation of endocrine development in the duct ligated pancreas
Venant Tchokonte-Nana
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Pdx-1-driven overexpression of aurora a kinase induces mild ductal dysplasia of pancreatic ducts near islets in transgenic mice
David Bearss
2008
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Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in mice
PEDRO MANUEL FONSECA HERRERA
Cancer research, 2003
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Deciphering the Mechanisms of Tumorigenesis in Human Pancreatic Ductal Epithelial Cells
Yaan Kang
Clinical Cancer Research, 2013
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The homeodomain protein PDX1 is required at mid-pancreatic development for the formation of the exocrine pancreas
Ling Shi
Developmental Biology, 2005
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