Inhibition of lysosomal phospholipase A and phospholipase C by chloroquine and 4,4'-bis(diethylaminoethoxy) alpha, beta-diethyldiphenylethane (original) (raw)

Studies on the mechanism of drug-induced lipidosis

Karl Y Hostetler

Biochemical Pharmacology, 1981

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Chloroquine treatment does not cause phospholipid storage by depleting rat liver lysosomes of acid phospholipase a

Karl Y Hostetler

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1984

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Studies on drug-induced lipidosis: subcellular localization of phospholipid and cholesterol in the liver of rats treated with chloroquine or 4,4'-bis (diethylaminoethoxy)alpha, beta-diethyldiphenylethane

Karl Y Hostetler

Journal of lipid research, 1980

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Drug-induced Phospholipidosis -Pathological Aspects and Its Prediction

Ryo Fukuda

Journal of Toxicologic Pathology, 2008

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Comparison of the Diagnostic Accuracy of Di-22:6-Bis(monoacylglycerol)Phosphate and Other Urinary Phospholipids for Drug-Induced Phospholipidosis or Tissue Injury in the Rat

Jun Zhang

International Journal of Toxicology, 2012

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Different Sensitivity of Macrophages to Phospholipidosis Induction by Amphiphilic Cationic Drugs

Eleonore Fröhlich

International Journal of Molecular Sciences, 2020

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Pharmacological properties of phospholipid liposomes

Gino Toffano

Pharmacological research communications, 1980

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Interactions of primaquine and chloroquine with PEGylated phosphatidylcholine liposomes

Noorma Rosita

Scientific Reports, 2021

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Increased levels of urinary phenylacetylglycine associated with mitochondrial toxicity in a model of drug-induced phospholipidosis

Hans Senn

Therapeutic advances in drug safety, 2013

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Lysosomal lipolytic enzymes, lipid peroxidation, and injury

William Weglicki

Molecular and Cellular Biochemistry, 1988

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Modulation of the in vitro activity of lysosomal phospholipase A1 by membrane lipids

Marie-Paule Mingeot

Chemistry and physics …, 2005

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Properties of phospholipase C isolated from rat liver lysosomes

Karl Y Hostetler

The Journal of biological chemistry, 1980

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Inhibition of kidney lysosomal phospholipases A and C by aminoglycoside antibiotics: possible mechanism of aminoglycoside toxicity

Karl Y Hostetler

Proceedings of the National Academy of Sciences, 1982

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Effect of local anesthetics on phospholipases from mitochondria and lysosomes. Probe into the role of the calcium ion in phospholipid hydrolysis

Patricia Sisson

Biochemistry, 1972

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A lipidomic cell-based assay for studying drug-induced phospholipidosis and steatosis

Agustín Lahoz

ELECTROPHORESIS, 2017

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In vitro inhibition of lysosomal phospholipase A1 of rat lung by amiodarone and desethylamiodarone

Karl Y Hostetler

Biochimica et biophysica acta, 1988

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The Contribution of Lysosomal Trapping in the Uptake of Desipramine and Chloroquine by Different Tissues

W. Daniel

Pharmacology & Toxicology, 1995

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Drug-induced surface membrane phospholipid composition in murine fibroblasts

Daniel Feller

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1981

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Lysosomotropic cationic drugs induce cytostatic and cytotoxic effects: Role of liposolubility and autophagic flux and antagonism by cholesterol ablation

Alexandre Parks

Toxicology and Applied Pharmacology, 2016

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Cellular Responses Associated with Dibucaine-Induced Phospholipidosis

José Manuel Pérez Martín

Chemical Research in Toxicology, 2011

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Modifications of phospholipid metabolism induced by chlorpromazine, desmethylimipramine and propranolol in C6 glioma cells

Ubaldo Leli

Biochemical Pharmacology, 1987

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Lipid peroxidation and phospholipase A2 activity in liposomes composed of unsaturated phospholipids: a structural basis for enzyme activation

Mary Lou Wratten

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1988

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Pharmacokinetic characterization of phosphatidylserine liposomes in the rat

Giampietro Viola

British Journal of Pharmacology, 1991

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Mechanism of modification of rat brain lysophospholipase A activity by cationic amphiphilic drugs

Ubaldo Leli

Biochimica et biophysica acta, 1987

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Selective Inhibition of Phosphatidylinositol Phospholipase C by Cytotoxic Ether Lipid Analogues

Catherine Gratas

Cancer Research

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The biologically active phospholipid, lysophosphatidic acid, induces phosphatidylcholine breakdown in fibroblasts via activation of phospholipase D. Comparison with the response to endothelin

John de Widt

The Biochemical journal, 1992

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Lysosomal Sequestration (Trapping) of Lipophilic Amine (Cationic Amphiphilic) Drugs in Immortalized Human Hepatocytes (Fa2N-4 Cells)

Faraz Kazmi

Drug Metabolism and Disposition, 2013

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Disturbance of lysosomal glycogen metabolism by liposomal anti-alpha-glucosidase and some anti-inflammatory drugs

Don Otter

Biochemical Journal, 1983

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Is Lysosomal Enzymes Changes Important In the Pathogenesis of Liver And Kidney Injury Induced By Short and Long Term Administration of Some NSAID ' Drugs in Rats ?

kamal eldeib

2012

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Cationic amphiphilic drugs induce elevation in lysoglycerophospholipid levels and cell death in leukemia cells

Inger Nielsen

Metabolomics, 2020

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Detection of Phospholipidosis Induction: A Cell-Based Assay in High-Throughput and High-Content Format

David Gerhold

2014

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