Thymus-antigen- and immunoglobulin-positive lymphocytes in tissue infiltrates of NZB/NZW mice (original) (raw)

The study investigates the lymphoid infiltrates in the salivary glands and kidneys of NZB/NZW mice, focusing on the presence of thymus antigen-positive (T) and immunoglobulin-positive (B) lymphocytes. Early lesions in the salivary glands are primarily composed of B cells, while T cells are associated with later-stage lesions. A proposed mechanism involves the sequential involvement of these lymphocyte populations in tissue damage, with implications for understanding similar autoimmune conditions in other species.