Angiomyolipoma of the upper lip: Case report and review of the literature (original) (raw)
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Angiomyolipoma of the Oral Cavity: A Rare Case Report
Journal of Dental and Maxillofacial Surgery
Angiomyolipoma (AML) is a rare, benign tumor composed of thick-wall blood vessels, smooth muscle component and mature adispose tissue. Differentiation from other benign and malignant mesenchymal lesions of oral cavity depends on recognition of these three histologic components, and immunohistochemical (IHC) techniques are also helpful. This tumor arise from perivascular epithelioid cells (PEComas) and kidneys followed by liver are the main locations of this soft tissue tumor. AMLs are rarely found in oral cavity and few case reports of oral AML have been reported in the literature. We report the first case of concurrent occurrence of AML of the tongue and peripheral giant cell granuloma of the gingiva in a 59-year-old patient. Clinically it was presented as a painless nodular mass with a smooth surface on the dorsal of the tongue. Based on histopathologic features and IHC staining the diagnosis of oral AML was done. The other lesion was a small sessile mass in interdental papillae o...
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 2010
Angiomyolipoma (AML) is the most common benign mesenchymal neoplasm of the kidneys with well-established clinical and morphological features. The oral and maxillofacial pathology literature contains several examples that identify angiomyomatous proliferations of the oral mucosa that contain an adipocytic component as analogous to classic renal AMLs although they differ significantly in their immunohistochemical phenotype. Herein, through review of the pertinent oral pathology literature and the detailed description of 2 lesions, one an oral angiomyoma with an adipocytic component and the other an apparently hamartomatous angioleiomyomatous proliferation with adipocytes, we provide, in our opinion, a solid argument against the use of the term AML for non-PEComatous oral tumors.
Non-infiltrating angiolipoma of the upper lip: A rare entity
Journal of Oral and Maxillofacial Pathology, 2012
Angiolipoma is a variant of lipoma with a prominent vascular component. It is the most common tumor of the forearm followed by trunk and extremities of young individuals. It's occurrence in head and neck region is rare. In this report, we present clinical and histopathologic features of non-infiltrating angiolipoma occurring on the upper lip in a 9-year-old female. Toluidine blue stain is used to demonstrate increased mast cell density around blood vessels, speculating its role in vasculogenesis.
Journal of Oral Science, 2013
Oral angiolipomas are exceedingly rare and little is known about their morphological and etiological features. Here, we report two cases of oral angiolipoma and discuss their clinicopathological and immunohistochemical features, focusing on endothelial markers. Both lesions presented mature adipocytes interspersed by small blood vessels containing fibrin thrombi. Immunohistochemical analysis showed numerous mast cells and expression of CD34, vascular endothelial growth factor, intercellular adhesion molecule-1, interferon-γ and interleukin 6 in most endothelial and stromal cells. Mast cell-endothelial cell interaction may be responsible for the reactive or neoplastic origin of the vascular proliferation of these entities. (J Oral Sci 55, 85-88, 2013)
Angiomyxolipoma is a rare histological variant of lipoma, characterized by proliferation of adipose tissue associated with a variable amount of myxoid stroma with numerous thick- and thin-walled blood vessels. An exhaustive literature review could reveal only 12 cases of angiomyxolipoma affecting subcutaneous tissue, subungual area and spermatic cord. In oral cavity, only 2 cases of angiomyxolipoma have been reported to date, one case in the buccal mucosa and one case in the floor of the mouth. Hence, this is only the third case of angiomyxolipoma affecting oral cavity and the first case of angiomyxolipoma of the tongue. We report a case of a 51-year male presenting with a swelling on the right lateral border of the tongue. The lesion was excised and microscopical examination confirmed the diagnosis of angiomyxolipoma.
Angioleiomyoma affecting the lips: Report of 3 cases and review of the literature
Medicina Oral Patología Oral y Cirugia Bucal, 2011
Angioleiomyoma is an uncommon benign soft tissue tumor usually found in the lower extremities and rarely observed in oral tissues. It is microscopically characterized as a proliferation of smooth muscle cells intermingled with abundant vascular channels. Oral angioleiomyomas affect mostly the lips, palate, buccal mucosa and tongue, and appears as a submucosal painless nodule. Upper lip is seldom affected and only few cases have been reported. We report three additional cases of angioleiomyoma affecting the lips of elderly patients. All lesions were asymptomatic and presented as submucosal nodules of approximately 1cm. Microscopic analysis on H&E sections revealed similar pattern in all cases, showing well-circumscribed and encapsulated tumors characterized by proliferation of smooth muscle cells and large amount of wide vascular spaces of varying sizes. Most tumor cells were immunoreactive for α-smooth muscle actin, desmin and HHF-35. CD34 was also positive on the endothelial cells. All patients were surgically treated and no recurrence was observed so far. The oral pathologists and clinicians should consider this entity when assessing nodular lesions on upper lip.
A rare case of oropharyngeal angiomyolipoma
IP innovative publication pvt. ltd, 2019
The authors here present a rare case of angiomyolipoma arising in the oropharynx. The tumor was found in a 55-year-old man, not associated with tuberous sclerosis. Histopathologic examination of the tumor revealed an admixture of numerous smooth muscle cells, mature adipose tissue and numerous thin –walled capillaries and thick-walled vessels. Both histological and immunohistochemical findings were typical for tumors of the mucocutaneous angiomyolipoma group.
Non Infiltrating Oral Angiolipoma – Report of A Rare Case with Review
Biomedical and Pharmacology Journal, 2021
The clinical presentation of typical lipomas is often characteristic. But the variations of lipoma based on the associated stroma poses a challenging picture with clinical diagnosis varying from benign tumors, various inflammatory and reactive lesions, salivary gland lesions, to few peripheral odontogenic lesions. Only a thorough clinical and pathological evaluation and correlation will help in arriving at a conclusive diagnosis, in understanding the behaviour, planning the treatment and predicting the prognosis of the lesion. One such case of lipoma presenting as an unassuming swelling clinically, but showing exuberant vascular component occurring on buccal mucosa is presented. A review of this variant of lipoma is discussed in comparison with the present case.