In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues (original) (raw)

The entomopathogenic fungus Beauveria bassiana produces bioactive cyclooligomer depsipeptides, specifically beauvericin and its analogues, which demonstrate a wide array of pharmacological properties. This study explores both in vitro and in vivo approaches to synthesize new beauvericin derivatives, highlighting their potential roles in medicinal applications across various diseases. The analysis of synthesis yields and NMR spectroscopic data provides insights into the chemical structure and potential therapeutic uses of these compounds.